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Substance Name: Debrisoquin sulfate [USAN]
RN: 581-88-4
UNII: Q94064N9NW
InChIKey: CAYGYVYWRIHZCQ-UHFFFAOYSA-N

Note

  • An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.

Molecular Formula

  • C10-H13-N3.1/2H2-O4-S

Molecular Weight

  • 448.545
 

Classification Codes

  • Antihypertensive
  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Debrisoquin sulfate
  • Debrisoquin sulfate [USAN]

Synonyms

  • 1,2,3,4-Tetrahydro-isoquinoline-2-carboxamidine sulfate
  • 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-, sulfate (2:1)
  • 3,4-Dihydro-2(1H)-isoquinolinecarboxamidine sulfate (2:1)
  • Debrisoquin hemisulfate
  • Debrisoquin sulfate
  • Declinax
  • EINECS 209-472-4
  • Equitonil
  • Isocaramidine sulfate
  • NSC 139330
  • Pasiron-T
  • Ro 5-3307/1
  • Tendor
  • UNII-Q94064N9NW

Systematic Names

  • 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-, sulfate (2:1)
  • Debrisoquine sulphate

Registry Numbers

CAS Registry Number

  • 581-88-4

FDA UNII

  • Q94064N9NW

System Generated Number

  • 0000581884

Molecular Formulas

Molecular Formula

  • C10-H13-N3.1/2H2-O4-S

Molecular Formula Fragments

  • C10-H13-N3
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/2C10H13N3.H2O4S/c2*11-10(12)13-6-5-8-3-1-2-4-9(8)7-13;1-5(2,3)4/h2*1-4H,5-7H2,(H3,11,12);(H2,1,2,3,4)

InChIKey

CAYGYVYWRIHZCQ-UHFFFAOYSA-N

Smiles

c12c(CCN(C1)C(N)=N)cccc2.c12c(CCN(C1)C(N)=N)cccc2.S(O)(O)(=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 132mg/kg (132mg/kg)   Current Therapeutic Research, Clinical & Experimental. Vol. 6, Pg. 299, 1964.
mouse LD50 intravenous 31700ug/kg (31.7mg/kg)   Current Therapeutic Research, Clinical & Experimental. Vol. 6, Pg. 299, 1964.
mouse LD50 oral 235mg/kg (235mg/kg)   Current Therapeutic Research, Clinical & Experimental. Vol. 6, Pg. 299, 1964.
mouse LD50 subcutaneous 136mg/kg (136mg/kg)   Current Therapeutic Research, Clinical & Experimental. Vol. 6, Pg. 299, 1964.
rat LD50 oral 610mg/kg (610mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 129, 1979.