|
|
Substance Name: Debrisoquin sulfate [USAN]
RN: 581-88-4
UNII: Q94064N9NW
InChIKey: CAYGYVYWRIHZCQ-UHFFFAOYSA-N
Note
- An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Molecular Formula
- C10-H13-N3.1/2H2-O4-S
Molecular Weight
- 448.545
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Antihypertensive
- Drug / Therapeutic Agent
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Debrisoquin sulfate
- Debrisoquin sulfate [USAN]
Synonyms
- 1,2,3,4-Tetrahydro-isoquinoline-2-carboxamidine sulfate
- 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-, sulfate (2:1)
- 3,4-Dihydro-2(1H)-isoquinolinecarboxamidine sulfate (2:1)
- Debrisoquin hemisulfate
- Debrisoquin sulfate
- Declinax
- EINECS 209-472-4
- Equitonil
- Isocaramidine sulfate
- NSC 139330
- Pasiron-T
- Ro 5-3307/1
- Tendor
- UNII-Q94064N9NW
Systematic Names
- 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-, sulfate (2:1)
- Debrisoquine sulphate
Registry Numbers
CAS Registry Number
- 581-88-4
FDA UNII
- Q94064N9NW
System Generated Number
- 0000581884
Molecular Formulas
Molecular Formula
- C10-H13-N3.1/2H2-O4-S
Molecular Formula Fragments
- C10-H13-N3
- COMPONENT
- H2-O4-S
Structure Descriptors
InChI
1S/2C10H13N3.H2O4S/c2*11-10(12)13-6-5-8-3-1-2-4-9(8)7-13;1-5(2,3)4/h2*1-4H,5-7H2,(H3,11,12);(H2,1,2,3,4)InChIKey
CAYGYVYWRIHZCQ-UHFFFAOYSA-NSmiles
c12c(CCN(C1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 132mg/kg (132mg/kg) | Current Therapeutic Research, Clinical & Experimental. Vol. 6, Pg. 299, 1964. | |
mouse | LD50 | intravenous | 31700ug/kg (31.7mg/kg) | Current Therapeutic Research, Clinical & Experimental. Vol. 6, Pg. 299, 1964. | |
mouse | LD50 | oral | 235mg/kg (235mg/kg) | Current Therapeutic Research, Clinical & Experimental. Vol. 6, Pg. 299, 1964. | |
mouse | LD50 | subcutaneous | 136mg/kg (136mg/kg) | Current Therapeutic Research, Clinical & Experimental. Vol. 6, Pg. 299, 1964. | |
rat | LD50 | oral | 610mg/kg (610mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE | Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 129, 1979. |