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Substance Name: GANU
RN: 58484-07-4
UNII: 1EU50CXT9P
InChIKey: ZOBLZIKVIHJGRN-JTFAZQEDSA-N

Note

  • Differs from chlorozotocin by placement of cytotoxic group on C-1 of the glucose ring; less myelosuppressive than chlorozotocin.

Molecular Formula

  • C9-H16-Cl-N3-O7

Molecular Weight

  • 313.6924
 

Classification Code

  • Mutation Data
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Names and Synonyms

Name of Substance

  • GANU

Synonyms

  • 1-(2-Chloroethyl)-3-(beta-D-glucopyranosyl)-1-nitrosourea
  • GANU
  • NSC D 254157
  • UNII-1EU50CXT9P

Systematic Names

  • N-(2-Chloroethyl)-N'-beta-D-glucopyranosyl-N-nitrosourea
  • Urea, 1-(2-chloroethyl)-3-(beta-D-glucopyranosyl)-1-nitroso-

Registry Numbers

CAS Registry Number

  • 58484-07-4

FDA UNII

  • 1EU50CXT9P

System Generated Number

  • 0058484074

Structure Descriptors

InChI

1S/C9H16ClN3O7/c10-1-2-13(12-19)9(18)11-8-7(17)6(16)5(15)4(3-14)20-8/h4-8,14-17H,1-3H2,(H,11,18)/t4-,5-,6+,7?,8-/m1/s1

InChIKey

ZOBLZIKVIHJGRN-JTFAZQEDSA-N

Smiles

C(CCl)N(C(=O)N[C@H]1C([C@H]([C@@H]([C@H](O1)CO)O)O)O)N=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD10 intravenous 10mg/kg (10mg/kg)   Antibiotics and Chemotherapy Vol. 23, Pg. 64, 1978.
mouse LD50 intraperitoneal 15mg/kg (15mg/kg)   Cancer Research. Vol. 37, Pg. 783, 1977.
rat LD50 intravenous 40mg/kg (40mg/kg)   Gann. Japanese Journal of Cancer Research. Vol. 68, Pg. 247, 1977.