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Substance Name: Anagrelide hydrochloride [USAN]
RN: 58579-51-4
UNII: VNS4435G39
InChIKey: TVWRQCIPWUCNMI-UHFFFAOYSA-N

Note

  • Imidazoquinazoline derivative which lowers platelet count probably by inhibiting thrombopoiesis and reduces platelet aggregation; used for thrombocythemia.

Molecular Formula

  • C10-H7-Cl2-N3-O.Cl-H

Molecular Weight

  • 292.5522
 

Classification Codes

  • Antithrombotic
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Fibrinolytic Agents
  • Hematologic Agents
  • Platelet Aggregation Inhibitors

Names and Synonyms

Name of Substance

  • Anagrelide hydrochloride [USAN]

Synonyms

  • 6,7-Dichloro-1,5-dihydroimidazo(2,1-b)-quinazolin-2(3H)-one monohydrochloride
  • Agrelin
  • Agrylin
  • Anagrelid hydrochlorid
  • Anagrelide HCl
  • Anagrelide hydrochloride
  • BL 4162A
  • BL-4162a
  • BMY 26538-01
  • Imidazo(2,1-b)quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-, monohydrochloride
  • SPD 422
  • Thromboreductin
  • UNII-VNS4435G39
  • Xagrid

Systematic Name

  • Imidazo(2,1-b)quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 58579-51-4

FDA UNII

  • VNS4435G39

System Generated Number

  • 0058579514

Molecular Formulas

Molecular Formula

  • C10-H7-Cl2-N3-O.Cl-H

Molecular Formula Fragments

  • C10-H7-Cl2-N3-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C10H7Cl2N3O.ClH/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7;/h1-2H,3-4H2,(H,13,14,16);1H

InChIKey

TVWRQCIPWUCNMI-UHFFFAOYSA-N

Smiles

Cl.Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD50 oral > 200mg/kg (200mg/kg)   New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 277, 1983.
mouse LD50 intraperitoneal 500mg/kg (500mg/kg)   New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 277, 1983.
mouse LD50 oral > 2500mg/kg (2500mg/kg)   New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 277, 1983.
rat LD50 oral > 1500mg/kg (1500mg/kg)   New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 277, 1983.