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Substance Name: Nomegestrol acetate [USAN]
RN: 58652-20-3
UNII: 83J78V5W05
InChIKey: IIVBFTNIGYRNQY-YQLZSBIMSA-N

Note

  • Do not confuse with Solastic.

Molecular Formula

  • C23-H30-O4

Molecular Weight

  • 370.486
 

Classification Codes

  • Hormone
  • Human Data
  • Prevention of Pregnancy in Women who Elect to use a Hormonal Contraceptive as a Method of Contraception
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Nomegestrol acetate [USAN]
  • TX 066

Synonyms

  • 17-alpha-Acetoxy-6-methyl-19-nor-4,6-pregnadiene-3,20-dione
  • 17-alpha-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione acetate
  • 19-Norpregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-methyl-
  • EINECS 261-379-8
  • NOMAC
  • Nomegestrol acetate
  • ORG 10486-0
  • TX 066
  • UNII-83J78V5W05

Systematic Names

  • 17-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione 17-acetate
  • 19-Norpregna-4,6-diene-3,20-dione, 17-alpha-hydroxy-6-methyl-, acetate

Registry Numbers

CAS Registry Number

  • 58652-20-3

FDA UNII

  • 83J78V5W05

System Generated Number

  • 0058652203

Structure Descriptors

InChI

1S/C23H30O4/c1-13-11-20-18(17-6-5-16(26)12-19(13)17)7-9-22(4)21(20)8-10-23(22,14(2)24)27-15(3)25/h11-12,17-18,20-21H,5-10H2,1-4H3/t17-,18-,20-,21+,22+,23+/m1/s1

InChIKey

IIVBFTNIGYRNQY-YQLZSBIMSA-N

Smiles

CC(=O)O[C@@]1(CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@@H]4[C@H]3CC[C@]12C)C(=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 2gm/kg (2000mg/kg)   Drugs of the Future. Vol. 9, Pg. 657, 1984.
mouse LD50 oral > 2gm/kg (2000mg/kg)   Drugs of the Future. Vol. 9, Pg. 657, 1984.
rat LD50 intraperitoneal > 2gm/kg (2000mg/kg)   Drugs of the Future. Vol. 9, Pg. 657, 1984.
rat LD50 oral > 2gm/kg (2000mg/kg)   Drugs of the Future. Vol. 9, Pg. 657, 1984.
women TDLo oral 1050ug/kg/21D (1.05mg/kg) ENDOCRINE: ESTROGENIC

ENDOCRINE: CHANGE IN LH

ENDOCRINE: EFFECT ON MENSTRUAL CYSLE
British Journal of Obstetrics and Gynaecology. Vol. 94, Pg. 1199, 1987.