|
|
Substance Name: Niceritrol [INN:BAN:DCF:JAN]
RN: 5868-05-3
UNII: F54EHJ34MV
InChIKey: KUEUWHJGRZKESU-UHFFFAOYSA-N
Note
- An ester of nicotinic acid that lowers cholesterol and triglycerides in total plasma and in the VLD- and LD-lipoprotein fractions.
Molecular Formula
- C29-H24-N4-O8
Molecular Weight
- 556.5286
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antimetabolites
- Drug / Therapeutic Agent
- Hypolipidemic Agents
- Lipid Regulating Agents
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Niceritrol
- Niceritrol [INN:BAN:DCF:JAN]
MeSH Heading
- Niceritrol
Synonyms
- 3-Pyridinecarboxylic acid, 2,2-bis(((3-pyridinylcarbonyl)oxy)methyl)-1,3-propanediyl ester
- 4-22-00-00376 (Beilstein Handbook Reference)
- BRN 0377170
- Bufor
- Cardiolipol
- EINECS 227-519-7
- Niceritrol
- Niceritrolum
- Niceritrolum [INN-Latin]
- Pentaerythritol tetranicotinate
- Perycit
- SK 1 (Pharmaceutical)
- UNII-F54EHJ34MV
Systematic Names
- 3-Pyridinecarboxylic acid, 2,2-bis(((3-pyridinylcarbonyl)oxy)methyl)-1,3-propanediyl ester
- Niceritrol
- Nicotinic acid, neopentanetetrayl ester
- Pentaerithritol tetranicotinate
Registry Numbers
CAS Registry Number
- 5868-05-3
FDA UNII
- F54EHJ34MV
System Generated Number
- 0005868053
Structure Descriptors
InChI
InChI=1S/C29H24N4O8/c34-25(21-5-1-9-30-13-21)38-17-29(18-39-26(35)22-6-2-10-31-14-22,19-40-27(36)23-7-3-11-32-15-23)20-41-28(37)24-8-4-12-33-16-24/h1-16H,17-20H2InChIKey
KUEUWHJGRZKESU-UHFFFAOYSA-NSmiles
O=C(OCC(COC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD | oral | > 5gm/kg (5000mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 741, 1977. | |
mouse | LD | intraperitoneal | > 10gm/kg (10000mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 741, 1977. | |
mouse | LD | oral | > 20gm/kg (20000mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 741, 1977. | |
mouse | LD | subcutaneous | > 5gm/kg (5000mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 741, 1977. | |
rabbit | LD | intraperitoneal | > 5gm/kg (5000mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 741, 1977. | |
rabbit | LD | oral | > 10gm/kg (10000mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 741, 1977. | |
rat | LD | intraperitoneal | > 5gm/kg (5000mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 741, 1977. | |
rat | LD | oral | > 20gm/kg (20000mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 741, 1977. | |
rat | LD | subcutaneous | > 5gm/kg (5000mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 741, 1977. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 162 | deg C | EXP | |
log P (octanol-water) | 1.910 | (none) | EST | |
Atmospheric OH Rate Constant | 7.83E-12 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.