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Substance Name: Cyclopentolate hydrochloride [USP:JAN]
RN: 5870-29-1
UNII: 736I6971TE
InChIKey: RHKZVMUBMXGOLL-UHFFFAOYSA-N

Note

  • A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia.

Molecular Formula

  • C17-H25-N-O3.Cl-H

Molecular Weight

  • 327.849
 

Classification Codes

  • Anticholinergic (Ophthalmic)
  • Drug / Therapeutic Agent
  • Human Data
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Names and Synonyms

Name of Substance

  • Cyclopentolate hydrochloride [USP:JAN]

Synonyms

  • 2-(Dimethylamino)ethyl (+-)-1-hydroxy-alpha-phenylcyclopentaneacetate hydrochloride
  • 2-(Dimethylamino)ethyl 1-hydroxy-alpha-phenylcyclopentaneacetate hydrochloride
  • AK-pentolate
  • Akpentolate
  • Benzeneacetic acid, alpha-(1-hydroxycyclopentyl)-, 2-(dimethylamino)ethyl ester, hydrochloride, (+-)-
  • beta-Dimethylaminoethyl (1-hydroxycyclopentyl)phenylacetate hydrochloride
  • Ciclolux
  • Cicloplegicedol
  • Cyclogyl
  • Cyclopentolate HCl
  • Cyclopentolate hydrochloride
  • Cyplegin
  • EINECS 227-521-8
  • Mydrilate
  • Pentolair
  • Skiacol
  • UNII-736I6971TE
  • Zyklolat

Systematic Names

  • 2-(2-(1-Hydroxycyclopentyl)-2-phenylacetoxy)ethyldimethylammonium chloride
  • Benzeneacetic acid, alpha-(1-hydroxycyclopentyl)-, 2-(dimethylamino)ethyl ester, hydrochloride
  • Cyclopentaneacetic acid, 1-hydroxy-alpha-phenyl-, 2-(dimethylamino)ethyl ester, hydrochloride

Mixture Name

  • Cyclomydril

Registry Numbers

CAS Registry Number

  • 5870-29-1

FDA UNII

  • 736I6971TE

System Generated Number

  • 0005870291

Molecular Formulas

Molecular Formula

  • C17-H25-N-O3.Cl-H

Molecular Formula Fragments

  • C17-H25-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H25NO3.ClH/c1-18(2)12-13-21-16(19)15(14-8-4-3-5-9-14)17(20)10-6-7-11-17;/h3-5,8-9,15,20H,6-7,10-13H2,1-2H3;1H

InChIKey

RHKZVMUBMXGOLL-UHFFFAOYSA-N

Smiles

C1([C@@H](c2ccccc2)C(OCCN(C)C)=O)(CCCC1)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo ocular 50ug/kg/I (0.05mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: TOXIC PSYCHOSIS
American Journal of Ophthalmology. Vol. 105, Pg. 91, 1988.
child TDLo subcutaneous 40ug/kg (0.04mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives of Ophthalmology Vol. 87, Pg. 634, 1972.
mouse LD50 intraperitoneal 314mg/kg (314mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 106, Pg. 141, 1952.
mouse LD50 intravenous 63mg/kg (63mg/kg)   Drugs in Japan Vol. -, Pg. 516, 1995.
mouse LD50 oral 960mg/kg (960mg/kg)   Drugs in Japan Vol. 6, Pg. 314, 1982.
mouse LD50 subcutaneous 292mg/kg (292mg/kg)   Drugs in Japan Vol. -, Pg. 444, 1990.
rat LD50 oral > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. 6, Pg. 314, 1982.
rat LD50 subcutaneous 2235mg/kg (2235mg/kg)   Drugs in Japan Vol. -, Pg. 444, 1990.