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Substance Name: Lonomycin A
RN: 58785-63-0
UNII: P54LV930KA
InChIKey: BKZOUCVNTCLNFF-IGXZVFLKSA-N

Note

  • Polyether antibiotic ionophore, polycyclic; lonomycin B is stereoisomer of lonomycin A.

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C44-H76-O14

Molecular Weight

  • 829.0704
 
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Names and Synonyms

Name of Substance

  • Lonomycin
  • Lonomycin A

Synonyms

  • Antibiotic DE 3936
  • Antibiotic TM 481
  • Emericid
  • UNII-P54LV930KA

Systematic Name

  • Lonomycin

Registry Numbers

CAS Registry Number

  • 58785-63-0

FDA UNII

  • P54LV930KA

Other Registry Numbers

  • 56832-67-8
  • 91196-09-7

Related Registry Number

  • 58845-80-0 (mono-hydrochloride salt)

System Generated Number

  • 0058785630

Structure Descriptors

InChI

1S/C44H76O14/c1-21-29(49-12)20-43(56-31(21)22(2)32-23(3)34(51-14)27(7)44(48,57-32)28(8)39(45)46)19-18-40(9,58-43)30-16-17-41(10,54-30)38-25(5)35(52-15)37(53-38)36-24(4)33(50-13)26(6)42(11,47)55-36/h21-38,47-48H,16-20H2,1-15H3,(H,45,46)/t21-,22-,23+,24+,25+,26-,27-,28-,29+,30-,31+,32-,33+,34+,35-,36+,37-,38-,40+,41+,42+,43-,44-/m1/s1

InChIKey

BKZOUCVNTCLNFF-IGXZVFLKSA-N

Smiles

CO[C@H]1C[C@]2(CC[C@](C)(O2)[C@H]3CC[C@](C)(O3)[C@@H]4O[C@H]([C@H](OC)[C@@H]4C)[C@H]5O[C@](C)(O)[C@H](C)[C@@H](OC)[C@@H]5C)O[C@H]([C@@H](C)[C@H]6O[C@@](O)([C@H](C)C(=O)O)[C@H](C)[C@@H](OC)[C@H]6C)[C@@H]1C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 oral 150mg/kg (150mg/kg)   Journal of Antibiotics. Vol. 29, Pg. 76-99, 1976.
mouse LD50 intraperitoneal 8280ug/kg (8.28mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 801, 1978.
mouse LD50 intravenous 4860ug/kg (4.86mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 801, 1978.
mouse LD50 oral 45800ug/kg (45.8mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 5, Pg. 482, 1981.
mouse LD50 subcutaneous 37500ug/kg (37.5mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 5, Pg. 482, 1981.