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Substance Name: Trichostatin A
RN: 58880-19-6
UNII: 3X2S926L3Z
InChIKey: RTKIYFITIVXBLE-QEQCGCAPSA-N

Notes

  • Chelates zinc ion in the active site of histone deacetylases, resulting in preventing histone unpacking so DNA is less available for transcription.
  • Chelates zinc ion in the active site of histone deacetylases, resulting in preventing histone unpacking so DNA is less available for transcription; found in STREPTOMYCES.

Molecular Formula

  • C17-H22-N2-O3

Molecular Weight

  • 302.372
 

Classification Codes

  • Anti-Infective Agents
  • Antibiotics, Antifungal
  • Antifungal Agents
  • Enzyme Inhibitors
  • Histone Deacetylase Inhibitors
  • Mutation Data
  • Protein Synthesis Inhibitors
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Names and Synonyms

Name of Substance

  • Trichostatin A

Synonyms

  • Trichostatin A
  • TSA
  • UNII-3X2S926L3Z

Systematic Names

  • 2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-
  • 2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)-
  • 7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

Registry Numbers

CAS Registry Number

  • 58880-19-6

FDA UNII

  • 3X2S926L3Z

System Generated Number

  • 0058880196

Structure Descriptors

InChI

1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1

InChIKey

RTKIYFITIVXBLE-QEQCGCAPSA-N

Smiles

c1cc(C([C@@H](\C=C(\C=C\C(NO)=O)C)C)=O)ccc1N(C)C