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Substance Name: Ubenimex [INN:JAN]
RN: 58970-76-6
UNII: I0J33N5627
InChIKey: VGGGPCQERPFHOB-RDBSUJKOSA-N
Note
- Growth inhibitor.
Molecular Formula
- C16-H24-N2-O4
Molecular Weight
- 308.376
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Adjuvants, Immunologic
- Anti-Bacterial Agents
- Anti-HIV Agents
- Anti-Infective Agents
- Anti-Retroviral Agents
- Antibiotics, Antineoplastic
- Antineoplastic Agents
- Antiviral Agents
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Immunologic Factors
- Natural Product
- Protease Inhibitors
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Ubenimex
- Ubenimex [INN:JAN]
Synonyms
- (-)-N-((2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl)-L-leucine
- 3-(R)-Amino-2-(S)-hydroxy-4-phenylbutanoyl-(S)-leucine
- Bestatin
- BRN 4704312
- EINECS 261-529-2
- NK 421
- NSC 265489
- Ubenimex
- Ubenimexum
- Ubenimexum [Latin]
- UNII-I0J33N5627
Systematic Names
- (-)-N-((2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl)-L-leucine
- (3-Amino-2-hydroxy-4-phenylbutanoyl)-L-leucine
- (S-(R*,S*))-N-(3-Amino-2-hydroxy-4-phenylbutyroyl)-L-leucine
- L-Leucine, N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-, (S-(R*,S*))-
Registry Numbers
CAS Registry Number
- 58970-76-6
FDA UNII
- I0J33N5627
System Generated Number
- 0058970766
Structure Descriptors
InChI
InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1InChIKey
VGGGPCQERPFHOB-RDBSUJKOSA-NSmiles
CC(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD | oral | > 1200mg/kg (1200mg/kg) | Japanese Journal of Antibiotics. Vol. 36, Pg. 2971, 1983. | |
mouse | LD | oral | > 4gm/kg (4000mg/kg) | Japanese Journal of Antibiotics. Vol. 36, Pg. 2971, 1983. | |
mouse | LD50 | intraperitoneal | 190mg/kg (190mg/kg) | Japanese Journal of Antibiotics. Vol. 36, Pg. 2971, 1983. | |
mouse | LD50 | intraperitoneal | 190mg/kg (190mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Japanese Journal of Antibiotics. Vol. 36, Pg. 2971, 1983. |
mouse | LD50 | subcutaneous | 1300mg/kg (1300mg/kg) | Japanese Journal of Antibiotics. Vol. 36, Pg. 2971, 1983. | |
mouse | LD50 | subcutaneous | 1300mg/kg (1300mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Japanese Journal of Antibiotics. Vol. 36, Pg. 2971, 1983. |
rat | LD | oral | > 2gm/kg (2000mg/kg) | Japanese Journal of Antibiotics. Vol. 36, Pg. 2971, 1983. | |
rat | LD50 | intraperitoneal | 780mg/kg (780mg/kg) | Japanese Journal of Antibiotics. Vol. 36, Pg. 2971, 1983. | |
rat | LD50 | intraperitoneal | 780mg/kg (780mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Japanese Journal of Antibiotics. Vol. 36, Pg. 2971, 1983. |
rat | LD50 | subcutaneous | 1900mg/kg (1900mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Japanese Journal of Antibiotics. Vol. 36, Pg. 2971, 1983. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 234.5 | deg C | EXP | |
log P (octanol-water) | 0.180 | (none) | EST | |
Atmospheric OH Rate Constant | 1.37E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.