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Substance Name: Ranimustine [INN:JAN]
RN: 58994-96-0
UNII: RYH2T97J77
InChIKey: AHHFEZNOXOZZQA-ZEBDFXRSSA-N

Classification Codes

  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect

Molecular Formula

  • C10-H18-Cl-N3-O7

Molecular Weight

  • 327.7192
 
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Names and Synonyms

Name of Substance

  • Ranimustine
  • Ranimustine [INN:JAN]

Synonyms

  • BRN 4762262
  • Cymerine
  • MCNU
  • Methyl 6-(3-(2-chloroethyl)-3-nitrosoureido)-6-deoxy-alpha-D-glucopyranoside
  • Methyl-6-(3-(2-chloroethyl)-3-nitrosoureido)-6-deoxy-alpha-D-glucopyranoside
  • NSC-0270516
  • Ranimustina
  • Ranimustina [Spanish]
  • Ranimustine
  • Ranimustinum
  • Ranimustinum [Latin]
  • Thymerin
  • UNII-RYH2T97J77

Systematic Names

  • alpha-D-Glucopyranoside, methyl 6-((((2-chloroethyl)nitrosoamino)carbonyl)amino)-6-deoxy-
  • Glucopyranoside, methyl-6-((((2-chloroethyl)nitrosoamino)carbonyl)amino)-6-deoxy-, alpha-D-
  • Methyl 6-(3-(2-chloroethyl)-3-nitrosoureido)-6-deoxy-alpha-D-glucopyranoside

Registry Numbers

CAS Registry Number

  • 58994-96-0

FDA UNII

  • RYH2T97J77

System Generated Number

  • 0058994960

Structure Descriptors

InChI

1S/C10H18ClN3O7/c1-20-9-8(17)7(16)6(15)5(21-9)4-12-10(18)14(13-19)3-2-11/h5-9,15-17H,2-4H2,1H3,(H,12,18)/t5-,6-,7+,8-,9+/m1/s1

InChIKey

AHHFEZNOXOZZQA-ZEBDFXRSSA-N

Smiles

CO[C@@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CNC(=O)N(CCCl)N=O)O)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 39mg/kg (39mg/kg)   Drugs in Japan Vol. -, Pg. 1238, 1990.
mouse LD50 intravenous 41200ug/kg (41.2mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BLOOD: CHANGES IN SPLEEN
Yakkyoku. Pharmacy. Vol. 38, Pg. 1513, 1987.
mouse LD50 oral 45700ug/kg (45.7mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 474, 1987.
rat LD50 intraperitoneal 37mg/kg (37mg/kg)   Drugs in Japan Vol. -, Pg. 1238, 1990.
rat LD50 intravenous 31800ug/kg (31.8mg/kg) BLOOD: CHANGES IN SPLEEN

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Yakkyoku. Pharmacy. Vol. 38, Pg. 1513, 1987.
rat LD50 oral 46400ug/kg (46.4mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 474, 1987.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 111 deg C   EXP
log P (octanol-water) -1.290 (none)   EST
Water Solubility 9000 mg/L 25 EXP
Atmospheric OH Rate Constant 6.62E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.