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Substance Name: Folic acid [USP:INN:BAN:JAN]
RN: 59-30-3
UNII: 935E97BOY8
InChIKey: OVBPIULPVIDEAO-LBPRGKRZSA-N

Note

  • A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.

Molecular Formula

  • C19-H19-N7-O6

Molecular Weight

  • 441.4021
 

Classification Codes

  • Drug / Therapeutic Agent
  • Growth Substances
  • Hematinics
  • Hematologic Agents
  • Micronutrients
  • Mutation Data
  • Reproductive Effect
  • Vitamin (Hematopoietic)
  • Vitamin B Complex
  • Vitamins

Names and Synonyms

Name of Substance

  • Folic acid
  • Folic acid [USP:INN:BAN:JAN]
  • L-Glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-
  • N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid

MeSH Heading

  • Folic acid

Synonyms

  • 4-Pteridinol, 2-amino-6-((p-((1,3-dicarboxypropyl)carbamoyl)anilino)methyl)-
  • Acfol (Spain)
  • Acide folique
  • Acide folique [INN-French]
  • Acido folico
  • Acido folico [INN-Spanish]
  • Acidum folicum
  • Acidum folicum [INN-Latin]
  • Acifolic
  • AI3-26387
  • Antianemia factor
  • CCRIS 666
  • Cytofol
  • EINECS 200-419-0
  • Facid
  • Factor U
  • Folacid
  • Folacin
  • Folaemin
  • Folaemin [Netherlands]
  • Folan
  • Folasic (Australia)
  • Folate
  • Folbal
  • Folcidin
  • Folcidin (VAN)
  • Folcysteine
  • Foldine
  • Foldine [France]
  • Folettes
  • Foliamin
  • Folic acid
  • Folicet
  • Folico
  • Folico (Italy)
  • Folina
  • Folina (Italy)
  • Folipac
  • Folsan
  • Folsaure
  • Folsav
  • Folvite
  • Glutamic acid, N-(p-(((2-amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-, L-
  • Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
  • Glutamic acid, pteroyl-, L-
  • HSDB 2002
  • Incafolic
  • Kyselina listova
  • Kyselina listova [Czech]
  • L-Glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-
  • L-Glutamic acid, N-(4-((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-
  • Liver Lactobacillus casei factor
  • Megafol
  • Millafol
  • Mittafol
  • N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
  • N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
  • Neocepri
  • Nifolin
  • Nifolin [Denmark]
  • Novofolacid
  • Novofolacid [Canada]
  • NSC 3073
  • PGA
  • PGA (VAN)
  • Pteglu
  • Pteroyl-L-glutamic acid
  • Pteroyl-L-monoglutamic acid
  • Pteroylglutamic acid
  • Pteroylmonoglutamate
  • Pteroylmonoglutamic acid
  • UNII-935E97BOY8
  • USAF CB-13
  • Vitamin B11
  • Vitamin B9
  • Vitamin Bc
  • Vitamin Be
  • Vitamin M

Systematic Names

  • Folic acid
  • L-Glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-
  • L-Glutamic acid, N-(4-(((2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-

Superlist Name

  • Folic acid

Mixture Name

  • Mission Prenatal

Registry Numbers

CAS Registry Number

  • 59-30-3

FDA UNII

  • 935E97BOY8

Other Registry Numbers

  • 11096-55-2
  • 33609-88-0

Related Registry Numbers

  • 36653-55-1 (mono-potassium salt)
  • 6484-89-5 (mono-hydrochloride salt)

System Generated Number

  • 0000059303

Structure Descriptors

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

InChIKey

OVBPIULPVIDEAO-LBPRGKRZSA-N

Smiles

c1cc(ccc1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCc2cnc3c(n2)c(=O)nc([nH]3)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 120mg/kg (120mg/kg)   Drugs in Japan Vol. -, Pg. 1409, 1995.
mouse LD50 intraperitoneal 85mg/kg (85mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: COMA
Experientia. Vol. 41, Pg. 72, 1985.
mouse LD50 intravenous 282mg/kg (282mg/kg)   Toxicology and Applied Pharmacology. Vol. 23, Pg. 537, 1972.
mouse LD50 oral 10gm/kg (10000mg/kg)   Toxicology and Applied Pharmacology. Vol. 23, Pg. 537, 1972.
mouse LDLo subcutaneous 200mg/kg (200mg/kg) BLOOD: CHANGES IN SPLEEN

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Proceedings of the Society for Experimental Biology and Medicine. Vol. 71, Pg. 544, 1949.
rabbit LD50 intravenous 410mg/kg (410mg/kg)   Drugs in Japan Vol. -, Pg. 1409, 1995.
rat LD50 intravenous 500mg/kg (500mg/kg)   Drugs in Japan Vol. -, Pg. 1409, 1995.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 250 dec deg C   EXP
log P (octanol-water) -2.810 (none)   EST
Water Solubility 1.6 mg/L 25 EXP
Vapor Pressure 3.37E-21 mm Hg 25 EST
Henry's Law Constant 3.55E-33 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.60E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.