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Substance Name: Chloropyramine [INN:BAN:DCF]
RN: 59-32-5
UNII: 2K3L8O9SOV
InChIKey: ICKFFNBDFNZJSX-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Histamine Agents
  • Histamine Antagonists
  • Histamine H1 Antagonists
  • Neurotransmitter Agents

Molecular Formula

  • C16-H20-Cl-N3

Molecular Weight

  • 289.808
 
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Names and Synonyms

Name of Substance

  • Chloropyramine
  • Chloropyramine [INN:BAN:DCF]

Synonyms

  • 2-((p-Chlorobenzyl)(2-(dimethylamino)ethyl)amino)pyridine
  • 2-((p-Chlorobenzyl)(2-dimethylaminoethyl)amino)pyridine
  • 4-22-00-03928 (Beilstein Handbook Reference)
  • Allergan S
  • Anaphylline
  • Avapena
  • BRN 0257085
  • Chlorneoantergan
  • Chloroneoantergan
  • Chloropyramine
  • Chloropyraminum
  • Chloropyraminum [INN-Latin]
  • Chloropyribenzamine
  • Chlorpyramine
  • Chlorpyraminum
  • Cloropiramina
  • Cloropiramina [INN-Spanish]
  • EINECS 200-421-1
  • Ethylenediamine, N-(p-chlorobenzyl)-N',N'-dimethyl-N-(2-pyridyl)-
  • Halopyramine
  • N-(p-Chlorobenzyl)-N',N'-dimethyl-N-(2-pyridyl)ethylenediamine
  • NSC 241038
  • p-Chlorbenzyl-alpha-pyridyl-dimethyl-aethylendiamin
  • p-Chlorbenzyl-alpha-pyridyl-dimethyl-aethylendiamin [German]
  • Suprastin
  • Synopen
  • Synopen R
  • Synpen
  • UNII-2K3L8O9SOV

Systematic Names

  • 1,2-Ethanediamine, N-((4-chlorophenyl)methyl)-N',N'-dimethyl-N-2-pyridinyl- (9CI)
  • 2-((p-Chlorobenzyl)(2-dimethylaminoethyl)amino)pyridine
  • Chloropyramine
  • Pyridine, 2-((p-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-

Registry Numbers

CAS Registry Number

  • 59-32-5

FDA UNII

  • 2K3L8O9SOV

Related Registry Numbers

  • 10458-04-5 (unspecified hydrochloride)
  • 6170-42-9 (mono-hydrochloride)

System Generated Number

  • 0000059325

Structure Descriptors

InChI

1S/C16H20ClN3/c1-19(2)11-12-20(16-5-3-4-10-18-16)13-14-6-8-15(17)9-7-14/h3-10H,11-13H2,1-2H3

InChIKey

ICKFFNBDFNZJSX-UHFFFAOYSA-N

Smiles

N(CCN(C)C)(c1ccccn1)Cc1ccc(cc1)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 108mg/kg (108mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1723, 1975.
mammal (species unspecified) LD50 subcutaneous 142mg/kg (142mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 131, 1957.
mouse LD50 intraperitoneal 79200ug/kg (79.2mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1723, 1975.
mouse LD50 intravenous 24100ug/kg (24.1mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1723, 1975.
mouse LD50 oral 354mg/kg (354mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1723, 1975.
rat LD50 intraperitoneal 104mg/kg (104mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1723, 1975.
rat LD50 intravenous 32500ug/kg (32.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1723, 1975.
rat LD50 oral 920mg/kg (920mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1723, 1975.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point < 25 deg C   EXP
log P (octanol-water) 3.370 (none)   EST
Atmospheric OH Rate Constant 1.28E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.