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Substance Name: Piperoxan [INN:BAN]
RN: 59-39-2
UNII: 9ZCS27634Y
InChIKey: LYKMMUBOEFYJQG-UHFFFAOYSA-N

Note

  • A benzodioxane alpha-adrenergic blocking agent with considerable stimulatory action. It has been used to diagnose PHEOCHROMOCYTOMA and as an antihypertensive agent.

Molecular Formula

  • C14-H19-N-O2

Molecular Weight

  • 233.309
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic alpha-Antagonists
  • Adrenergic Antagonists
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Neurotransmitter Agents
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Names and Synonyms

Name of Substance

  • Piperoxan
  • Piperoxan [INN:BAN]

MeSH Heading

  • Piperoxan

Synonyms

  • 5-20-03-00452 (Beilstein Handbook Reference)
  • 933F
  • Benodaine
  • BRN 0222516
  • F933
  • Fourneau 933
  • Piperidine, 1-(1,4-benzodioxan-2-ylmethyl)-
  • Piperoxan
  • Piperoxane
  • Piperoxane [INN-French]
  • Piperoxano
  • Piperoxano [INN-Spanish]
  • Piperoxanum
  • Piperoxanum [INN-Latin]
  • UNII-9ZCS27634Y

Systematic Names

  • 1,4-Benzodioxan, 2-(piperidinomethyl)-
  • 2-Piperidinomethyl-1,4-benzodioxan
  • Piperidine, 1-((2,3-dihydro-1,4-benzodioxin-2-yl)methyl)- (9CI)

Registry Numbers

CAS Registry Number

  • 59-39-2

FDA UNII

  • 9ZCS27634Y

System Generated Number

  • 0000059392

Structure Descriptors

InChI

1S/C14H19NO2/c1-4-8-15(9-5-1)10-12-11-16-13-6-2-3-7-14(13)17-12/h2-3,6-7,12H,1,4-5,8-11H2

InChIKey

LYKMMUBOEFYJQG-UHFFFAOYSA-N

Smiles

c12c(OC[C@@H](O1)CN1CCCCC1)cccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 175mg/kg (175mg/kg)   Journal of Medicinal and Pharmaceutical Chemistry. Vol. 5, Pg. 1285, 1962.
rabbit LD50 intravenous 35mg/kg (35mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 105, Pg. 317, 1956.