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Substance Name: Mephenesin [INN:BAN:NF]
RN: 59-47-2
UNII: 7B8PIR2954
InChIKey: JWDYCNIAQWPBHD-UHFFFAOYSA-N

Note

  • A centrally acting muscle relaxant with a short duration of action.

Molecular Formula

  • C10-H14-O3

Molecular Weight

  • 182.218
 

Classification Codes

  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Muscle Relaxants, Central
  • Neuromuscular Agents
  • Peripheral Nervous System Agents
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Names and Synonyms

Name of Substance

  • Mephenesin
  • Mephenesin [INN:BAN:NF]

MeSH Heading

  • Mephenesin

Synonyms

  • 1,2-Dihydroxy-3-(2-methylphenoxy)propane
  • 1-o-Tolylglycerol ether
  • 1-Ortho-tolylglycerol ether
  • 3-(2-Methylphenoxy)-1,2-propanediol
  • 3-(2-Tolyloxy)-1,2-propanediol
  • 3-(o-Methylphenoxy)-1,2-propanediol
  • 3-(o-Tolyloxy)propane-1,2-diol
  • 3-o-Toloxy-1,2-propanediol
  • 4-06-00-01952 (Beilstein Handbook Reference)
  • A 1141
  • Ageflex CGE
  • alpha,beta-Dihydroxy-gamma-(2-methylphenoxy)propane
  • alpha-(o-Tolyl)glyceryl ether
  • Anatensin
  • Anxine
  • Atensin
  • Avesyl
  • Avosyl
  • Avoxil
  • Avoxyl
  • BDH 312
  • BRN 2047373
  • BYK-M 1
  • Cresodiol
  • Cresossidiolo
  • Cresossipropandiolo
  • Cresoxydiol
  • Cresoxypropanediol
  • Curaril
  • Curarythan
  • Curythan
  • Daserd
  • Daserol
  • Decontractil
  • Decontractyl
  • Diloxol
  • Dioloxal
  • Dioloxol
  • EINECS 200-427-4
  • Findolar
  • Findolor
  • Glukresin
  • Glyceryl o-tolyl ether
  • Glykresin
  • Glyotol
  • Glytol
  • Halabar
  • Kinavosyl
  • Kresoxypropandiol
  • Lissenphan
  • Lissephen
  • MC 2303
  • Mefenesina
  • Mefenesina [INN-Spanish]
  • Memphenesin
  • Mephate
  • Mephedan
  • Mephelor
  • Mephenesin
  • Mephenesine
  • Mephenesine [INN-French]
  • Mephenesinum
  • Mephenesinum [INN-Latin]
  • Mepherol
  • Mephesin
  • Mephin
  • Mephosal
  • Mephson
  • Mervaldin
  • Mianesina
  • Miolisina
  • Moctynol
  • Myanesin
  • Myanil
  • Myanol
  • Myasin
  • Myastenin
  • Myocuran
  • Myodetensin
  • Myodetensine
  • Myolax
  • Myolyseen
  • Myolysin
  • Myopan
  • Myopen
  • Myopna
  • Myosera
  • Myoserol
  • Myoten
  • Myoxane
  • Myoxyl
  • Nembusen
  • Nephelor
  • Noctynol
  • NSC 25234
  • o-Cresol glyceryl ether
  • o-Cresyl alpha-glyceryl ether
  • o-Cresyl glycerol ether
  • o-Kresol-glycerinaether
  • o-Kresol-glycerinaether [German]
  • Oranixon
  • Ortol
  • Prolax
  • Prolaxin
  • Proloxin
  • Relaxant
  • Relaxar
  • Relaxil
  • Relaxyl
  • Renarcol
  • Rhex 'hobeino'
  • Rhex regulans
  • RP 3602
  • Sansdolor
  • Saserol
  • Seconesinz
  • Sinan
  • Spartoloxin
  • Spartoloxyn
  • Spasmolyn
  • SQ 1156
  • Stilalgin
  • Temian
  • Thioxidil
  • Thoxidil
  • Tokerol
  • Tolansin
  • Tolax
  • Tolbart
  • Tolcil
  • Tolhart
  • Tolofren
  • Tolosate
  • Toloxyn
  • Tolserol
  • Tolsil
  • Tolsin
  • Tolulexin
  • Tolulox
  • Tolydrin
  • Tolynol
  • Tolyspaz
  • Torulox
  • UNII-7B8PIR2954
  • Walko-nesin
  • Xeral

Systematic Names

  • 1,2-Propanediol, 3-(2-methylphenoxy)-
  • 1,2-Propanediol, 3-(o-tolyloxy)-
  • 3-(o-Methylphenoxy)-1,2-propanediol
  • Mephenesin

Registry Numbers

CAS Registry Number

  • 59-47-2

FDA UNII

  • 7B8PIR2954

System Generated Number

  • 0000059472

Structure Descriptors

InChI

1S/C10H14O3/c1-8-4-2-3-5-10(8)13-7-9(12)6-11/h2-5,9,11-12H,6-7H2,1H3

InChIKey

JWDYCNIAQWPBHD-UHFFFAOYSA-N

Smiles

c1cccc(OC[C@@H](CO)O)c1C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
hamster LD50 intraperitoneal 322mg/kg (322mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: MUSCLE WEAKNESS
Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960.
hamster LD50 oral 821mg/kg (821mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960.
mouse LD50 intraperitoneal 320mg/kg (320mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 55, Pg. 1272, 1959.
mouse LD50 intravenous 175mg/kg (175mg/kg)   Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 248, Pg. 3642, 1959.
mouse LD50 oral 720mg/kg (720mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 242, 1967.
mouse LD50 subcutaneous 285mg/kg (285mg/kg) BEHAVIORAL: ANTICONVULSANT Acta Pharmacologica et Toxicologica. Vol. 19, Pg. 247, 1962.
rabbit LD50 intravenous 125mg/kg (125mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: REGIDITY
International Journal of Neuropharmacology. Vol. 5, Pg. 305, 1966.
rabbit LDLo oral 2300mg/kg (2300mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 89, Pg. 145, 1952.
rat LD50 intraperitoneal 283mg/kg (283mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA
Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960.
rat LD50 intravenous 133mg/kg (133mg/kg) KIDNEY, URETER, AND BLADDER: HEMATURIA

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Proceedings of the Society for Experimental Biology and Medicine. Vol. 85, Pg. 323, 1954.
rat LD50 oral 625mg/kg (625mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ANTIPSYCHOTIC
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 130, Pg. 280, 1961.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 70 dec deg C   EXP
log P (octanol-water) 1.41 (none)   EXP
Water Solubility 1.18E+04 mg/L 20 EXP
Vapor Pressure 5.43E-06 mm Hg 25 EST
Henry's Law Constant 8.29E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 4.81E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.