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Substance Name: Tolazoline hydrochloride [USP:JAN]
RN: 59-97-2
UNII: E669Z6S1JG
InChIKey: RHTNTTODYGNRSP-UHFFFAOYSA-N

Note

  • A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.

Molecular Formula

  • C10-H12-N2.Cl-H

Molecular Weight

  • 196.6797
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Vasodilator (Peripheral)
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Names and Synonyms

Name of Substance

  • Tolazoline hydrochloride [USP:JAN]

Synonyms

  • 2-Benzyl-2-imidazoline monohydrochloride
  • 2-Imidazoline, 2-benzyl-, hydrochloride
  • 4,5-Dihydro-2-(phenylmethyl)-1H-imidazole monohydrochloride
  • AI3-52042
  • Arterodyl
  • Benzazoline hydrochloride
  • Benzylimidazoline hydrochloride
  • Cloridrato di 2-benzil-4,5-imidazolina
  • Cloridrato di 2-benzil-4,5-imidazolina [Italian]
  • EINECS 200-447-3
  • Imidaline hydrochloride
  • Priscoline
  • Priscoline hydrochloride
  • Tolavad
  • Tolazoline chloride
  • Tolazoline HCl
  • Tolazoline hydrochloride
  • Tolpal
  • UNII-E669Z6S1JG

Systematic Names

  • 1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-, hydrochloride (1:1)
  • 1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-, monohydrochloride
  • 2-Imidazoline, 2-benzyl-, monohydrochloride
  • Tolazoline hydrochloride

Registry Numbers

CAS Registry Number

  • 59-97-2

FDA UNII

  • E669Z6S1JG

Other Registry Numbers

  • 245547-27-7
  • 7380-28-1

Related Registry Number

  • 59-98-3 (Parent)

System Generated Number

  • 0000059972

Molecular Formulas

Molecular Formula

  • C10-H12-N2.Cl-H

Molecular Formula Fragments

  • C10-H12-N2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C10H12N2.ClH/c1-2-4-9(5-3-1)8-10-11-6-7-12-10;/h1-5H,6-8H2,(H,11,12);1H

InChIKey

RHTNTTODYGNRSP-UHFFFAOYSA-N

Smiles

Cl.C(C1=NCCN1)c2ccccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo intravenous 150ug/kg (0.15mg/kg) CARDIAC: CHANGE IN RATE

VASCULAR: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): SWEATING: OTHER
Folia Medica Vol. 27, Pg. 729, 1941.
infant TDLo intravenous 48mg/kg/47H-C (48mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM DUODENUM

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
Australian Paediatric Journal. Vol. 22, Pg. 221, 1986.
mouse LD50 intraperitoneal 130mg/kg (130mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1992, 1971.
mouse LD50 intravenous 56700ug/kg (56.7mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Journal of Pharmacobio-Dynamics. Vol. 9, Pg. 395, 1986.
mouse LD50 oral 400mg/kg (400mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1992, 1971.
rat LD50 intraperitoneal 100mg/kg (100mg/kg)   Drugs in Japan Vol. 6, Pg. 511, 1982.
rat LD50 intravenous 85mg/kg (85mg/kg)   Drugs in Japan Vol. 6, Pg. 511, 1982.
rat LD50 oral 1200mg/kg (1200mg/kg)   Drugs in Japan Vol. 6, Pg. 511, 1982.