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Substance Name: Nafazatrom [INN:BAN]
RN: 59040-30-1
UNII: K94216221B
InChIKey: ISBUYSPRIJRBKX-UHFFFAOYSA-N

Classification Codes

  • Antineoplastic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Fibrin Modulating Agents
  • Fibrinolytic Agents
  • Hematologic Agents
  • Lipoxygenase Inhibitors

Molecular Formula

  • C16-H16-N2-O2

Molecular Weight

  • 268.314
 
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Names and Synonyms

Name of Substance

  • Nafazatrom
  • Nafazatrom [INN:BAN]

Synonyms

  • 2,4-Dihydro-5-methyl-2-(2-(2-naphthalenyloxy)ethyl)-3H-pyrazol-3-one
  • 3-Methyl-1-(2-(2-naphthyloxy)ethyl)-2-pyrazolin-5-one
  • Bay g 6575
  • BAY-g 6575
  • BRN 0665222
  • EINECS 261-571-1
  • Nafazatrom
  • Nafazatromum
  • Nafazatromum [INN-Latin]
  • UNII-K94216221B

Systematic Names

  • 3-Methyl-1-(2-(2-naphthyloxy)ethyl)-2-pyrazolin-5-one
  • 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-(2-(2-naphthalenyloxy)ethyl)-
  • Nafazatrom

Registry Numbers

CAS Registry Number

  • 59040-30-1

FDA UNII

  • K94216221B

System Generated Number

  • 0059040301

Structure Descriptors

InChI

1S/C16H16N2O2/c1-12-10-16(19)18(17-12)8-9-20-15-7-6-13-4-2-3-5-14(13)11-15/h2-7,11H,8-10H2,1H3

InChIKey

ISBUYSPRIJRBKX-UHFFFAOYSA-N

Smiles

c12c(cc(OCCN3N=C(C)CC3=O)cc1)cccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 10gm/kg (10000mg/kg)   Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983-Vol. 2, Pg. 13, 1984.
dog LD50 intravenous 100mg/kg (100mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
New Cardiovascular Drugs. Vol. 4, Pg. 163, 1986.
mouse LD oral > 10gm/kg (10000mg/kg)   Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983-Vol. 2, Pg. 13, 1984.
mouse LD50 intravenous 77mg/kg (77mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
New Cardiovascular Drugs. Vol. 4, Pg. 163, 1986.
rabbit LD oral > 10gm/kg (10000mg/kg)   Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983-Vol. 2, Pg. 13, 1984.
rabbit LD50 intravenous 25mg/kg (25mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
New Cardiovascular Drugs. Vol. 4, Pg. 163, 1986.
rat LD oral > 10gm/kg (10000mg/kg)   Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983-Vol. 2, Pg. 13, 1984.
rat LD50 intravenous 76mg/kg (76mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
New Cardiovascular Drugs. Vol. 4, Pg. 163, 1986.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 2.74 (none)   EXP
Water Solubility 85.4 mg/L 25 EST
Vapor Pressure 2.21E-08 mm Hg 25 EST
Henry's Law Constant 2.16E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.36E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.