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Substance Name: Haloxazolam [INN:JAN]
RN: 59128-97-1
UNII: M448L2V8XP
InChIKey: XDKCGKQHVBOOHC-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C17-H14-Br-F-N2-O2

Molecular Weight

  • 377.2116
 
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Names and Synonyms

Name of Substance

  • Haloxazolam
  • Haloxazolam [INN:JAN]

Synonyms

  • 10-Bromo-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydrooxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one
  • 10-Bromo-11b-(o-fluorophenyl)-2,3,7,11b-tetrahydrooxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one
  • BRN 0569670
  • CS 430
  • CS-430
  • Haloxazolam
  • Haloxazolamum
  • Haloxazolamum [INN-Latin]
  • Somelin
  • UNII-M448L2V8XP

Systematic Names

  • 10-Bromo-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydrooxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one
  • 10-Bromo-11b-(o-fluorophenyl)-2,3,7,11b-tetrahydrooxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one
  • Oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one, 2,3,7,11b-tetrahydro-10-bromo-11b-(2-fluorophenyl)-

Superlist Names

  • DEA No. 2771
  • Haloxazolam

Registry Numbers

CAS Registry Number

  • 59128-97-1

FDA UNII

  • M448L2V8XP

System Generated Number

  • 0059128971

Structure Descriptors

InChI

1S/C17H14BrFN2O2/c18-11-5-6-15-13(9-11)17(12-3-1-2-4-14(12)19)21(7-8-23-17)10-16(22)20-15/h1-6,9H,7-8,10H2,(H,20,22)

InChIKey

XDKCGKQHVBOOHC-UHFFFAOYSA-N

Smiles

c1ccc(c(c1)C23c4cc(ccc4NC(=O)CN2CCO3)Br)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
infant TDLo oral 2mg/kg (2mg/kg) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

BEHAVIORAL: SLEEP
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 38, Pg. 2597, 1996.
mouse LD50 intraperitoneal > 15gm/kg (15000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 1501, 1980.
mouse LD50 oral 1413mg/kg (1413mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 27, Pg. 64, 1975.
mouse LD50 subcutaneous > 15gm/kg (15000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 1501, 1980.
rat LD50 intraperitoneal > 3gm/kg (3000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 1501, 1980.
rat LD50 oral 2858mg/kg (2858mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 27, Pg. 64, 1975.
rat LD50 subcutaneous > 3gm/kg (3000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 1501, 1980.