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Substance Name: Methylazoxymethanol acetate
RN: 592-62-1
UNII: 4C7R36N7Q7
InChIKey: BELPJCDYWUCHKF-WAYWQWQTSA-N

Note

  • The aglycone of CYCASIN. It acts as a potent carcinogen and neurotoxin and inhibits hepatic DNA, RNA, and protein synthesis.

Molecular Formula

  • C4-H8-N2-O3

Molecular Weight

  • 132.1182
 

Classification Codes

Classification Codes

  • Enzyme Inhibitors
  • Mutation Data
  • Neurotoxins
  • Noxae
  • Nucleic Acid Synthesis Inhibitors
  • Protein Synthesis Inhibitors
  • Reproductive Effect
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 2B
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Names and Synonyms

Name of Substance

  • Methylazoxymethanol acetate

MeSH Heading

  • Methylazoxymethanol acetate

Synonyms

  • (Methyl-ONN-azoxy)methanol, acetate (ester)
  • Acetic acid, (methyl-ONN-azoxy)methyl ester
  • BRN 2324754
  • CCRIS 383
  • Cycasin acetate
  • EINECS 209-765-7
  • HSDB 4323
  • Mam ac
  • MAM acetate
  • Methanol, (methyl-ONN-azoxy)-, acetate (ester)
  • Methyl azoxy methanol acetate
  • Methylazoxymethanol acetate
  • Methylazoxymethyl acetate
  • Methylazoxymethylester kyseliny octove
  • Methylazoxymethylester kyseliny octove [Czech]
  • NSC 87705
  • UNII-4C7R36N7Q7

Systematic Names

  • (Methyl-ONN-azoxy)methyl acetate
  • Methanol, (methyl-ONN-azoxy)-, acetate (ester)
  • Methylazoxymethanol acetate

Superlist Names

  • Methanol, (methyl-ONN-azoxy)-, acetate (ester)
  • Methylazoxymethanol acetate
  • Methylazoxymethyl acetate

Registry Numbers

CAS Registry Number

  • 592-62-1

FDA UNII

  • 4C7R36N7Q7

System Generated Number

  • 0000592621

Structure Descriptors

InChI

1S/C4H8N2O3/c1-4(7)9-3-5-6(2)8/h3H2,1-2H3/b6-5-

InChIKey

BELPJCDYWUCHKF-WAYWQWQTSA-N

Smiles

CC(=O)OCN=[N+](C)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 105mg/kg (105mg/kg)   JNCI, Journal of the National Cancer Institute. Vol. 62, Pg. 911, 1979.
mouse LD50 intravenous 10mg/kg (10mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04566,
mouse LDLo oral 35mg/kg (35mg/kg)   Cancer Research. Vol. 30, Pg. 801, 1970.
rat LDLo intraperitoneal 50mg/kg (50mg/kg)   Chemico-Biological Interactions. Vol. 17, Pg. 291, 1977.