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Substance Name: Ribonuclease
RN: 9001-99-4
InChIKey: YKLNVEHYEFWWHA-UHFFFAOYSA-N

Notes

  • An enzyme that catalyzes the endonucleolytic cleavage of pancreatic ribonucleic acids to 3'-phosphomono- and oligonucleotides ending in cytidylic or uridylic acids with 2',3'-cyclic phosphate intermediates. EC 3.1.27.5.
  • Enzymes that catalyze the hydrolysis of ester bonds within RNA. EC 3.1.-.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Mutation Data
  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)
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Names and Synonyms

Name of Substance

  • Ribonuclease

MeSH Headings

  • Ribonuclease, Pancreatic
  • Ribonucleases

Synonyms

  • Alkaline ribonuclease
  • Binase
  • E.C. 2.7.7.16
  • E.C. 3.1.4.22
  • EINECS 232-646-6
  • Gigantin
  • Interleukin 2 mRNA-selective ribonuclease
  • Keratinocyte-derived RNase-like factor
  • Lactoribonuclease
  • Onconase
  • Pancreatic ribonuclease
  • Pancreatic RNase
  • Ribonuclease
  • Ribonuclease A
  • Ribonuclease beef pancreas
  • Ribonuclease I
  • Ribonucleic phosphatase
  • RNAase
  • S-RNase

Systematic Names

  • Nuclease, ribo-
  • Ribonuclease

Registry Numbers

CAS Registry Number

  • 9001-99-4

Other Registry Numbers

  • 102227-38-3
  • 102227-40-7
  • 81989-91-5
  • 9038-12-4
  • 9081-35-0

System Generated Number

  • 0009001994

Structure Descriptors

InChI

1S/C20H24N2O2S/c1-13(21-20(2,3)4)19(23)22-15-8-6-7-9-17(15)25-18-11-10-14(24-5)12-16(18)22/h6-13,21H,1-5H3

InChIKey

YKLNVEHYEFWWHA-UHFFFAOYSA-N

Smiles

CC(C(=O)N1c2ccccc2Sc3c1cc(cc3)OC)NC(C)(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 355mg/kg (355mg/kg)   "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie. Nucleases: Biological Function and Practical Applications," Berdyshev, G.D., et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985Vol. -, Pg. 56, 1985.
mouse LD50 intraperitoneal 250mg/kg (250mg/kg)   "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie. Nucleases: Biological Function and Practical Applications," Berdyshev, G.D., et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985Vol. -, Pg. 56, 1985.
mouse LD50 subcutaneous 230mg/kg (230mg/kg)   "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie. Nucleases: Biological Function and Practical Applications," Berdyshev, G.D., et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985Vol. -, Pg. 56, 1985.
rat LD50 intramuscular 310mg/kg (310mg/kg)   "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie. Nucleases: Biological Function and Practical Applications," Berdyshev, G.D., et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985Vol. -, Pg. 56, 1985.
rat LD50 intraperitoneal 392mg/kg (392mg/kg)   "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie. Nucleases: Biological Function and Practical Applications," Berdyshev, G.D., et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985Vol. -, Pg. 56, 1985.
rat LD50 subcutaneous 290mg/kg (290mg/kg)   "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie. Nucleases: Biological Function and Practical Applications," Berdyshev, G.D., et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985Vol. -, Pg. 56, 1985.