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Substance Name: Fenethazine hydrochloride
RN: 5934-20-3
UNII: 225AVG0161
InChIKey: CKIPCLCBYTWUEZ-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C16-H18-N2-S.Cl-H

Molecular Weight

  • 306.8591
 
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Names and Synonyms

Name of Substance

  • Fenethazine hydrochloride

Synonyms

  • 10-(2-(Dimethylamino)ethyl)-phenothiazine hydrochloride
  • 3015 R.P.
  • Anergen hydrochloride
  • EINECS 227-685-0
  • Ethysine hydrochloride
  • Etisine hydrochloride
  • Etizin
  • Fenethazine hydrochloride
  • Lisergan hydrochloride
  • N-Dimethylaminoethylphenothiazine hydrochloride
  • NSC 54546
  • Phenothiazine, 10-(2-(dimethylamino)ethyl)-, hydrochloride
  • Rutergan hydrochloride
  • SC 1627 hydrochloride
  • UNII-225AVG0161

Systematic Names

  • 10H-Phenothiazine-10-ethanamine, N,N-dimethyl-, monohydrochloride (9CI)
  • N,N-Dimethyl-10H-phenothiazine-10-ethylamine monohydrochloride
  • Phenothiazine, 10-(2-(dimethylamino)ethyl)-, hydrochloride
  • Phenothiazine, 10-(2-(dimethylamino)ethyl)-, monohydrochloride (8CI)

Registry Numbers

CAS Registry Number

  • 5934-20-3

FDA UNII

  • 225AVG0161

System Generated Number

  • 0005934203

Molecular Formulas

Molecular Formula

  • C16-H18-N2-S.Cl-H

Molecular Formula Fragments

  • C16-H18-N2-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C16H18N2S.ClH/c1-17(2)11-12-18-13-7-3-5-9-15(13)19-16-10-6-4-8-14(16)18;/h3-10H,11-12H2,1-2H3;1H

InChIKey

CKIPCLCBYTWUEZ-UHFFFAOYSA-N

Smiles

CN(C)CCN1c2ccccc2Sc3c1cccc3.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 intraperitoneal 174mg/kg (174mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 328, 1953.
mouse LD50 intraperitoneal 140mg/kg (140mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 90, Pg. 224, 1947.
mouse LD50 subcutaneous 224mg/kg (224mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 54, Pg. 33, 1958.
rabbit LDLo intravenous 20mg/kg (20mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) Farmakologiya i Toksikologiya Vol. 20(1), Pg. 23, 1957.
rat LDLo intravenous 30mg/kg (30mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) Farmakologiya i Toksikologiya Vol. 20(1), Pg. 23, 1957.