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Substance Name: Nikkomycin
RN: 59456-70-1
UNII: 9Z22C3QQCJ
InChIKey: WWJFFVUVFNBJTN-VHDFTHOZSA-N
Note
- Nucleoside-peptide antibiotic which inhibits fungal chitin biosynthesis by inhibiting chitin synthase; consists of uracil, an amino hexuronic acid & a new amino acid containing a pyridine ring.
Molecular Formula
- C20-H25-N5-O10
Molecular Weight
- 495.4425
Classification Codes
- Anti-Infective Agents
- Antibiotics, Antifungal
- Antifungal Agents
- Drug / Therapeutic Agent
- Enzyme Inhibitors
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Names and Synonyms
Name of Substance
- Nikkomycin
Synonyms
- BRN 0873216
- Neopolyoxin C
- Nikkomycin Z
- NSC 601906
- UNII-9Z22C3QQCJ
Systematic Name
- beta-D-Allofuranuronic acid, 5-((2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl)amino)-1,5-dideoxy-1-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-, (2S-(2R*,3R*,4R*))-
Registry Numbers
CAS Registry Number
- 59456-70-1
FDA UNII
- 9Z22C3QQCJ
Other Registry Number
- 75044-70-1
System Generated Number
- 0059456701
Structure Descriptors
InChI
1S/C20H25N5O10/c1-7(13(28)9-3-2-8(26)6-22-9)11(21)17(31)24-12(19(32)33)16-14(29)15(30)18(35-16)25-5-4-10(27)23-20(25)34/h2-7,11-16,18,26,28-30H,21H2,1H3,(H,24,31)(H,32,33)(H,23,27,34)/t7-,11-,12-,13-,14-,15+,16+,18+/m0/s1InChIKey
WWJFFVUVFNBJTN-VHDFTHOZSA-NSmiles
C[C@H]([C@@H](c1ccc(cn1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD | intravenous | > 250mg/kg (250mg/kg) | Agricultural and Biological Chemistry. Vol. 44, Pg. 1709, 1980. |