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Substance Name: Midazolam [USP:INN:BAN:JAN]
RN: 59467-70-8
UNII: R60L0SM5BC
InChIKey: DDLIGBOFAVUZHB-UHFFFAOYSA-N
Note
- A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
Molecular Formula
- C18-H13-Cl-F-N3
Molecular Weight
- 325.7727
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Adjuvants, Anesthesia
- Anesthetics
- Anesthetics, General
- Anesthetics, Intravenous
- Anti-Anxiety Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- GABA Agents
- GABA Modulators
- Human Data
- Hypnotics and Sedatives
- Mutation Data
- Neurotransmitter Agents
- Psychotropic Drugs
- Reproductive Effect
- Tranquilizing Agents
Superlist Classification Code
- DEA Schedule IV
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Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Midazolam
- Midazolam [USP:INN:BAN:JAN]
MeSH Heading
- Midazolam
Synonyms
- 8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepin
- 8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine
- BRN 0625572
- Dormicum
- EINECS 261-774-5
- HSDB 6751
- Midazolam
- Midazolamum
- Midazolamum [INN-Latin]
- Ro 21-3981
- UNII-R60L0SM5BC
- USL261
Systematic Names
- 4H-Imidazo(1,5-a)(1,4)benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl-
- Midazolam
Superlist Names
- DEA No. 2884
- Midazolam
Registry Numbers
CAS Registry Number
- 59467-70-8
FDA UNII
- R60L0SM5BC
System Generated Number
- 0059467708
Structure Descriptors
InChI
InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3InChIKey
DDLIGBOFAVUZHB-UHFFFAOYSA-NSmiles
Cc1ncc2CN=C(c3ccccc3F)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
child | TDLo | oral | 500ug/kg (0.5mg/kg) | BEHAVIORAL: EXCITEMENT | Annals of Emergency Medicine. Vol. 24, Pg. 1173, 1994. |
mouse | LD50 | intramuscular | > 50mg/kg (50mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl, |
mouse | LD50 | intravenous | 50mg/kg (50mg/kg) | British Journal of Clinical Pharmacology. Vol. 16, Pg. 37S, 1983. | |
mouse | LDLo | oral | 500mg/kg (500mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl, |
rat | LD50 | intramuscular | > 50mg/kg (50mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl, |
rat | LD50 | intravenous | 75mg/kg (75mg/kg) | British Journal of Clinical Pharmacology. Vol. 16, Pg. 37S, 1983. | |
rat | LD50 | oral | 215mg/kg (215mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl, |
women | TDLo | intravenous | 74ug/kg/1M-C (0.074mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Australian and New Zealand Journal of Medicine. Vol. 25, Pg. 743, 1995. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 159 | deg C | EXP | |
log P (octanol-water) | 4.330 | (none) | EST | |
Atmospheric OH Rate Constant | 1.16E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.