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Substance Name: Midazolam maleate [USAN]
RN: 59467-94-6
UNII: 77520S18SE
InChIKey: XYGVIBXOJOOCFR-BTJKTKAUSA-N

Note

  • A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.

Molecular Formula

  • C18-H13-Cl-F-N3.C4-H4-O4

Molecular Weight

  • 441.8443
 

Classification Codes

  • Anesthetic (Intravenous)
  • Drug / Therapeutic Agent

Names and Synonyms

Name of Substance

  • Midazolam maleate [USAN]

Synonyms

  • 4H-Imidazo(1,5-a)(1,4)benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl-, (Z)-2-butenedioate (1:1)
  • 8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine maleate (1:1)
  • Dormicum maleate
  • EINECS 261-775-0
  • Midazolam maleate
  • Ro 21-3981/001
  • UNII-77520S18SE

Systematic Names

  • 4H-Imidazo(1,5-a)(1,4)benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl-, (Z)-2-butenedioate (1:1)
  • 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine monomaleate

Registry Numbers

CAS Registry Number

  • 59467-94-6

FDA UNII

  • 77520S18SE

Other Registry Number

  • 65607-69-4

System Generated Number

  • 0059467946

Molecular Formulas

Molecular Formula

  • C18-H13-Cl-F-N3.C4-H4-O4

Molecular Formula Fragments

  • C18-H13-Cl-F-N3
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C18H13ClFN3.C4H4O4/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13;5-3(6)1-2-4(7)8/h2-9H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChIKey

XYGVIBXOJOOCFR-BTJKTKAUSA-N

Smiles

Cc1ncc2n1-c3ccc(cc3C(=NC2)c4ccccc4F)Cl.C(=C\C(=O)O)\C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 86mg/kg (86mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 2180, 1981.
mouse LD50 oral 760mg/kg (760mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 2180, 1981.