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Substance Name: Megestrol acetate [USAN:USP]
RN: 595-33-5
UNII: TJ2M0FR8ES
InChIKey: RQZAXGRLVPAYTJ-GQFGMJRRSA-N

Note

  • Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. It also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia. (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995).

Molecular Formula

  • C24-H32-O4

Molecular Weight

  • 384.5128
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
  • Antineoplastic Agents, Hormonal
  • Appetite Stimulants
  • Central Nervous System Agents
  • Central Nervous System Stimulants
  • Hormone
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Megestrol acetate [USAN:USP]

MeSH Heading

  • Megestrol Acetate

Synonyms

  • 17-Acetoxy-6-methylpregna-4,6-diene-3,20-dione
  • 17-alpha-Acetoxy-6-dehydro-6-methylprogesterone
  • 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione 17-acetate
  • 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate
  • 17alpha-Acetoxy-6-dehydro-6-methylprogesterone
  • 17alpha-Acetoxy-6-methylpregna-4,6-diene-3,20-dione
  • 17alpha-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate
  • 5071
  • 6-Dehydro-6-methyl-17-alpha-acetoxyprogesterone
  • 6-Dehydro-6-methyl-17alpha-acetoxyprogesterone
  • 6-Methyl-17-alpha-acetoxypregna-4,6-diene-3,20-dione
  • 6-Methyl-17-alpha-hydroxy-delta(sup 6)-progesterone acetate
  • 6-Methyl-17alpha-hydroxy-delta(sup 6)-progesterone acetate
  • 6-Methyl-6-dehydro-17-alpha-acetoxyprogesterone
  • 6-Methyl-6-dehydro-17alpha-acetoxyprogesterone
  • 6-Methyl-delta(sup 4,6)-pregnadien-17-alpha-ol-3,20-dione acetate
  • 6-Methyl-delta(sup 6)-dehydro-17-alpha-acetoxyprogesterone
  • 6-Methyl-delta4,6-pregnadien-17alpha-ol-3,20-dione acetate
  • BDH 1298
  • CCRIS 372
  • DMAP
  • EINECS 209-864-5
  • Magestin
  • Maygace
  • Megace
  • Megace ES
  • Megeron
  • Megestat
  • Megestrol acetate
  • Megestryl acetate
  • Niagestin
  • NSC-71423
  • Ovaban
  • Ovaban (Veterinary)
  • Ovarid
  • Pallace
  • SC 10363
  • SC10363
  • UNII-TJ2M0FR8ES

Systematic Names

  • 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione 17-acetate
  • Megestrol acetate
  • Pregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-methyl-
  • Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-, acetate

Superlist Names

  • Megestrol acetate
  • Megestrol acetole
  • Megestrol acetole [Progestins]

Registry Numbers

CAS Registry Number

  • 595-33-5

FDA UNII

  • TJ2M0FR8ES

System Generated Number

  • 0000595335

Structure Descriptors

InChI

InChI=1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h12-13,18-20H,6-11H2,1-5H3/t18-,19+,20+,22-,23+,24+/m1/s1

InChIKey

RQZAXGRLVPAYTJ-GQFGMJRRSA-N

Smiles

CC(=O)O[C@@]1(CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C)C(=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 56mg/kg (56mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00931,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 214 deg C   EXP
log P (octanol-water) 4.000 (none)   EST
Water Solubility 2 mg/L 37 EXP
Atmospheric OH Rate Constant 2.55E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.