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Substance Name: Pancreatic polypeptide
RN: 59763-91-6


  • A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.

Classification Codes

  • Gastrointestinal Agents
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
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Links to Resources

Names and Synonyms

Name of Substance

  • Pancreatic polypeptide

MeSH Heading

  • Pancreatic polypeptide


  • PP 1420
  • PP1420
  • UNII-UDH73690IV

Systematic Name

  • Pancreatic polypeptide

Registry Numbers

CAS Registry Number

  • 59763-91-6


  • UDH73690IV

System Generated Number

  • 0059763916