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Substance Name: Levorphanol dl-form hydrobromide
RN: 5985-35-3
UNII: 5URK043N48
InChIKey: WVFGKGPFQSEWON-DYWKTHLTSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C17-H23-N-O.Br-H

Molecular Weight

  • 338.287
 
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Names and Synonyms

Name of Substance

  • Levorphanol dl-form hydrobromide

Synonyms

  • (+-)-17-Methylmorphinan-3-ol hydrobromide
  • dl-3-Hydroxy-N-methylmorphinan hydrobromide
  • Dromoran hydrobromide
  • Morphinan, 3-hydroxy-N-methyl-, hydrobromide, (+-)-
  • NSC 117861
  • Racemorphan hydrobromide
  • Ro 1-5431
  • UNII-5URK043N48

Systematic Names

  • Morphinan-3-ol, 17-methyl-, hydrobromide
  • Morphinan-3-ol, 17-methyl-, hydrobromide, (+-)-

Registry Numbers

CAS Registry Number

  • 5985-35-3

FDA UNII

  • 5URK043N48

System Generated Number

  • 0005985353

Molecular Formulas

Molecular Formula

  • C17-H23-N-O.Br-H

Molecular Formula Fragments

  • Br-H
  • C17-H23-N-O
  • COMPONENT

Structure Descriptors

InChI

1S/C17H23NO.BrH/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17;/h5-6,11,14,16,19H,2-4,7-10H2,1H3;1H/t14-,16+,17+;/m0./s1

InChIKey

WVFGKGPFQSEWON-DYWKTHLTSA-N

Smiles

c12[C@@]34[C@H]([C@@H](Cc1ccc(c2)O)[N@](C)CC3)CCCC4.Br

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 120mg/kg (120mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: STIFFNESS
Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 163, 1950.
mouse LD50 intravenous 33mg/kg (33mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 85, Pg. 387, 1951.
mouse LD50 oral 375mg/kg (375mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.
mouse LD50 subcutaneous 108mg/kg (108mg/kg)   Anesthesiology. Vol. 12, Pg. 225, 1951.
rabbit LD50 intravenous 19mg/kg (19mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 85, Pg. 387, 1951.
rat LD50 oral 350mg/kg (350mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.
rat LD50 subcutaneous 108mg/kg (108mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 85, Pg. 387, 1951.