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Substance Name: Benoxinate hydrochloride [USP]
RN: 5987-82-6
UNII: 0VE4U49K15
InChIKey: PRGUDWLMFLCODA-UHFFFAOYSA-N

Classification Codes

  • Anesthetic (Topical)
  • Drug / Therapeutic Agent

Molecular Formula

  • C17-H28-N2-O3.Cl-H

Molecular Weight

  • 344.8801
 
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Names and Synonyms

Name of Substance

  • Benoxinate hydrochloride [USP]

Synonyms

  • 2-(Diethylamino)ethyl 4-amino-3-butoxybenzoate monohydrochloride
  • Benoxil
  • Benoxinate HCl
  • Benoxinate hydrochloride
  • Cebesine
  • Conjuncain
  • Dorsacaine
  • Dorsacaine hydrochloride
  • EINECS 227-808-8
  • Lacrimin
  • Minims Benoxinate
  • Novesin
  • Novesina
  • Novesine
  • Opulets Benoxinate
  • Oxbarukain
  • Oxybuprocaine hydrochloride
  • UNII-0VE4U49K15

Systematic Names

  • 2-(Diethylamino)ethyl 4-amino-3-butoxybenzoate hydrochloride
  • Benzoic acid, 4-amino-3-butoxy-, 2-(diethylamino)ethyl ester, monohydrochloride

Mixture Name

  • Fluress

Registry Numbers

CAS Registry Number

  • 5987-82-6

FDA UNII

  • 0VE4U49K15

Related Registry Number

  • 99-43-4 (Parent)

System Generated Number

  • 0005987826

Molecular Formulas

Molecular Formula

  • C17-H28-N2-O3.Cl-H

Molecular Formula Fragments

  • C17-H28-N2-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H28N2O3.ClH/c1-4-7-11-21-16-13-14(8-9-15(16)18)17(20)22-12-10-19(5-2)6-3;/h8-9,13H,4-7,10-12,18H2,1-3H3;1H

InChIKey

PRGUDWLMFLCODA-UHFFFAOYSA-N

Smiles

CCCCOc1cc(ccc1N)C(=O)OCCN(CC)CC.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 4200ug/kg (4.2mg/kg)   Drugs in Japan Vol. -, Pg. 232, 1990.
guinea pig LD50 subcutaneous 21mg/kg (21mg/kg)   Drugs in Japan Vol. -, Pg. 232, 1990.
mouse LD50 intravenous > 6800ug/kg (6.8mg/kg)   Drugs in Japan Vol. -, Pg. 232, 1990.
mouse LD50 subcutaneous 42500ug/kg (42.5mg/kg)   Drugs in Japan Vol. 6, Pg. 154, 1982.
rabbit LD50 subcutaneous 30mg/kg (30mg/kg)   Drugs in Japan Vol. -, Pg. 232, 1990.
rabbit LD50 unreported 5600ug/kg (5.6mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1957, 1974.
rat LD50 intravenous > 5600ug/kg (5.6mg/kg)   Drugs in Japan Vol. -, Pg. 232, 1990.
rat LD50 subcutaneous 60mg/kg (60mg/kg)   Drugs in Japan Vol. 6, Pg. 154, 1982.