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Substance Name: (d)-Limonene
RN: 5989-27-5
UNII: GFD7C86Q1W
InChIKey: XMGQYMWWDOXHJM-JTQLQIEISA-N

Molecular Formula

  • C10-H16

Molecular Weight

  • 136.2364
 

Classification Codes

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 3

Names and Synonyms

Results Name

  • (d)-Limonene

Name of Substance

  • (d)-Limonene
  • D-limonene [JAN]
  • Limonene, D-

Synonyms

  • (+)-(4R)-Limonene
  • (+)-4-Isopropenyl-1-methylcyclohexene
  • (+)-alpha-Limonene
  • (+)-Dipentene
  • (+)-Limonene
  • (+)-p-Mentha-1,8-diene
  • (+)-R-Limonene
  • (4R)-(+)-Limonene
  • (4R)-Limonene
  • (R)-(+)-Limonene
  • (R)-(+)-p-Mentha-1,8-diene
  • (R)-1-Methyl-4-(1-methylethenyl)cyclohexene
  • (R)-4-Isopropenyl-1-methyl-1-cyclohexene
  • (R)-Limonene
  • (R)-p-Mentha-1,8-diene
  • 1-Methyl-4-(1-methylethenyl)cyclohexene, (R)-
  • AI3-15191
  • Biogenic SE 374
  • Carvene
  • CCRIS 671
  • Citrene
  • D-(+)-Limonene
  • D-Limonene
  • d-Limonene (natural)
  • d-Limoneno
  • d-Limoneno [Spanish]
  • d-p-Mentha-1,8-diene
  • EC 227-813-5
  • EC 7
  • EINECS 227-813-5
  • FEMA No. 2633
  • Glidesafe
  • Glidsafe
  • HSDB 4186
  • Kautschiin
  • Limonene, (+)-
  • NCI-C55572
  • p-Mentha-1,8-diene, (R)-(+)-
  • Refchole
  • UNII-GFD7C86Q1W

Systematic Names

  • (R)-p-Mentha-1,8-diene
  • Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (4R)-
  • Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-
  • Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (theta)-
  • D-Limonene

Superlist Names

  • D-Limonene
  • Limonene, D-
  • p-Mentha-1,8-diene, (R)-(+)-

Registry Numbers

CAS Registry Number

  • 5989-27-5

FDA UNII

  • GFD7C86Q1W

Other Registry Numbers

  • 1051930-86-9
  • 7705-13-7
  • 94765-75-0
  • 95327-98-3

System Generated Number

  • 0005989275

Structure Descriptors

InChI

1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3/t10-/m0/s1

InChIKey

XMGQYMWWDOXHJM-JTQLQIEISA-N

Smiles

C([C@@H]1CCC(C)=CC1)(C)=C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 skin > 5gm/kg (5000mg/kg)   Food and Cosmetics Toxicology. Vol. 12, Pg. 703, 1974.
mouse LD50 intraperitoneal 600mg/kg (600mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1439, 1974.
mouse LD50 oral 5600mg/kg (5600mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 387, 1975.
mouse LD50 subcutaneous 3170mg/kg (3170mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE Sapporo Igaku Zasshi. Sapporo Medical Journal. Vol. 3, Pg. 73, 1952.
mouse LDLo intraduodenal 1gm/kg (1000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1439, 1974.
mouse LDLo intraduodenal 1gm/kg (1000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1439, 1974.
rabbit LD50 skin > 5gm/kg (5000mg/kg)   Food and Cosmetics Toxicology. Vol. 13, Pg. 825, 1975.
rat LD50 intraperitoneal 3600mg/kg (3600mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 387, 1975.
rat LD50 intravenous 110mg/kg (110mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 387, 1975.
rat LD50 oral 4400mg/kg (4400mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 387, 1975.
rat LDLo subcutaneous 30200mg/kg (30200mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: EXCITEMENT

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 387, 1975.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -7.43E+01 deg C   EXP
Boiling Point 176 deg C   EXP
log P (octanol-water) 4.57 (none)   EXP
Water Solubility 13.8 mg/L 25 EXP
Vapor Pressure 1.98 mm Hg 25 EXP
Henry's Law Constant 0.026 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.71E-10 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.