Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Guanethidine sulfate [USAN:USP:JAN]
RN: 60-02-6
UNII: 8AQ60474G9
InChIKey: NBJGGHFXCGHTNJ-UHFFFAOYSA-N

Note

  • An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.

Molecular Formula

  • C10-H22-N4.1/2H2-O4-S

Molecular Weight

  • 494.7014
 

Classification Codes

  • Antihypertensive
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Guanethidine sulfate [USAN:USP:JAN]

Synonyms

  • (2-(Hexahydro-1(2H)-azocinyl)ethyl)guanidine sulfate (2:1)
  • AI3-52043
  • Azocine, 1-(2-guanidinoethyl)octahydro-, sulfate (2:1)
  • beta-1-Azacyclooctylethylguanidine sulfate
  • EINECS 200-452-0
  • Guanethidine sulfate
  • Guanetidin sulfate
  • Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-, sulfate (2:1)
  • Guanidine, (2-(octahydro-1-azocinyl)ethyl)-, hemisulfate
  • Guanidine, (2-(octahydro-1-azocinyl)ethyl)-, sulfate (2:1)
  • Iporal
  • Ismelin sulfate (2:1)
  • Isobarin
  • NSC-29863
  • SU-5864
  • UNII-8AQ60474G9

Systematic Names

  • Guanethidine sulphate
  • Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-, sulfate (2:1)

Registry Numbers

CAS Registry Number

  • 60-02-6

FDA UNII

  • 8AQ60474G9

Related Registry Number

  • 55-65-2 (Parent)

System Generated Number

  • 0000060026

Molecular Formulas

Molecular Formula

  • C10-H22-N4.1/2H2-O4-S

Molecular Formula Fragments

  • C10-H22-N4
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/2C10H22N4.H2O4S/c2*11-10(12)13-6-9-14-7-4-2-1-3-5-8-14;1-5(2,3)4/h2*1-9H2,(H4,11,12,13);(H2,1,2,3,4)

InChIKey

NBJGGHFXCGHTNJ-UHFFFAOYSA-N

Smiles

C1CCCN(CCC1)CCNC(=N)N.C1CCCN(CCC1)CCNC(=N)N.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 112mg/kg (112mg/kg)   U.S.S.R. Patent Document. Vol. #0822829,
mouse LD50 intravenous 18mg/kg (18mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#08547,
mouse LD50 oral 1100mg/kg (1100mg/kg)   U.S.S.R. Patent Document. Vol. #0822829,
mouse LD50 subcutaneous 278mg/kg (278mg/kg)   U.S.S.R. Patent Document. Vol. #0822829,
rat LD50 intravenous 23mg/kg (23mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 128, Pg. 22, 1960.
rat LD50 oral 1gm/kg (1000mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 128, Pg. 22, 1960.