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Substance Name: Amphetamine sulfate [USP]
RN: 60-13-9
UNII: 6DPV8NK46S
InChIKey: PYHRZPFZZDCOPH-UHFFFAOYSA-N

Note

  • A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.

Molecular Formula

  • C9-H13-N.1/2H2-O4-S

Molecular Weight

  • 368.4952
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Stimulant (Central)
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Amphetamine sulfate
  • Amphetamine sulfate [USP]

Synonyms

  • (+-)-2-Amino-1-phenylpropane sulfate
  • (+-)-alpha-Methylphenethylamine sulfate (2:1)
  • (+-)-Amphetamine sulfate
  • (+-)-Phenisopropylamine sulfate
  • 1-Phenyl-2-aminopropane sulfate
  • Adiparthrol
  • Aktedrin
  • Alentol
  • alpha-Methylphenethylamine sulfate, (+-)-
  • Amphamine sulfate
  • Amphetamine sulfate
  • Amphetamine sulphate
  • Amphetamini sulfas
  • Amphetaminium sulfuricum
  • Amphoids-S
  • Anara
  • Astedin
  • Bennie
  • Benzadrine
  • Benzafinyl
  • Benzedrine
  • Benzedrine sulfate
  • Benzies
  • Benzpropamine
  • Betafen
  • Betaphen
  • Bluzedrin
  • Cartwheels
  • CCRIS 3644
  • Centramina
  • CERM 1767
  • Desoxynorephedrine sulfate
  • Dietamine
  • DL-1-Phenyl-2-aminopropane sulfate
  • dl-alpha-Methylphenethylamine sulfate
  • DL-Amphetamine hydrogen sulfate
  • dl-Amphetamine sulphate
  • dl-Phenamine sulfate
  • Durophet
  • EINECS 200-457-8
  • Euphobine
  • Euphodine
  • Euphodyn
  • Fabedrine
  • Fenamin
  • Fenara
  • Fenedrin
  • Fenopromin sulfate
  • Halloo-wach
  • Ibiozedrine
  • Leodrin
  • Mimetina
  • Monetamine
  • NCI-C55710
  • Noclon
  • NSC 170999
  • Oraldrina
  • Ortenal
  • Peaches
  • Penamine (VAN)
  • Pharmamedrine
  • Phenamine (sympathomimetic)
  • Phenamine sulfate
  • Phenaminum
  • Phenisopropylamine sulfate
  • Phenopromin
  • Phenpromin
  • Propisamine
  • Psychedrine
  • Psychedrinum
  • Psychedryna
  • Psychoton
  • Racephen
  • Raphetamine
  • Razemisches phenylaminopropansulfat
  • Rhinalator
  • Roses
  • Sedolin
  • Simpamina
  • Simpamine
  • Simpatedrin
  • Stimulan
  • Sympametin
  • Sympamine
  • Sympatedrine
  • Synsatedrine
  • Theptine
  • UNII-6DPV8NK46S
  • Vapedrine
  • Weckamine
  • Zedrine

Systematic Names

  • Amphetamine sulphate
  • Benzeneethanamine, alpha-methyl-, sulfate
  • Benzeneethanamine, alpha-methyl-, sulfate (2:1), (+-)-
  • DL-Amphetamine sulfate
  • Phenethylamine, alpha-methyl-, sulfate (2:1), (+-)-

Superlist Name

  • DL-Amphetamine sulfate

Mixture Name

  • Adderall

Registry Numbers

CAS Registry Number

  • 60-13-9

FDA UNII

  • 6DPV8NK46S

Other Registry Number

  • 156-31-0

Related Registry Number

  • 300-62-9 (Parent)

System Generated Number

  • 0000060139

Molecular Formulas

Molecular Formula

  • C9-H13-N.1/2H2-O4-S

Molecular Formula Fragments

  • C9-H13-N
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/2C9H13N.H2O4S/c2*1-8(10)7-9-5-3-2-4-6-9;1-5(2,3)4/h2*2-6,8H,7,10H2,1H3;(H2,1,2,3,4)

InChIKey

PYHRZPFZZDCOPH-UHFFFAOYSA-N

Smiles

CC(Cc1ccccc1)N.CC(Cc1ccccc1)N.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 intraperitoneal 125mg/kg (125mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Toxicology and Applied Pharmacology. Vol. 2, Pg. 558, 1960.
chicken LD50 intravenous 70mg/kg (70mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Toxicology and Applied Pharmacology. Vol. 2, Pg. 558, 1960.
dog LD50 intravenous 6mg/kg (6mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 118, Pg. 557, 1965.
dog LD50 oral 23mg/kg (23mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 118, Pg. 557, 1965.
domestic animals - goat/sheep LDLo subcutaneous 15mg/kg (15mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
American Journal of the Medical Sciences. Vol. 198, Pg. 785, 1939.
frog LD50 parenteral 280mg/kg (280mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Journal of Pharmacology and Experimental Therapeutics. Vol. 76, Pg. 375, 1942.
guinea pig LD50 subcutaneous 105mg/kg (105mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 137, Pg. 375, 1962.
guinea pig LDLo intraperitoneal 50mg/kg (50mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 267, 1950.
human TDLo oral 41mg/kg (41mg/kg) CARDIAC: CHANGE IN RATE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ANOREXIA (HUMAN
Klinische Wochenscrift. Vol. 17, Pg. 1580, 1938.
monkey LDLo subcutaneous 5mg/kg (5mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
American Journal of the Medical Sciences. Vol. 198, Pg. 785, 1939.
mouse LD50 intraperitoneal 13mg/kg (13mg/kg)   Pharmaceutical Chemistry Journal Vol. 26, Pg. 430, 1992.
mouse LD50 intravenous 31800ug/kg (31.8mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: EXCITEMENT
Toxicology and Applied Pharmacology. Vol. 2, Pg. 558, 1960.
mouse LD50 oral 24mg/kg (24mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 711, 1963.
mouse LD50 subcutaneous 7mg/kg (7mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 170, Pg. 428, 1967.
rabbit LDLo intravenous 22mg/kg (22mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal de Physiologie et de Pathologie Generale. Vol. 37, Pg. 597, 1939.
rat LD50 intraperitoneal 125mg/kg (125mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 132, Pg. 97, 1961.
rat LD50 oral 55mg/kg (55mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 711, 1963.
rat LD50 subcutaneous 160mg/kg (160mg/kg) BEHAVIORAL: EXCITEMENT

LIVER: OTHER CHANGES
Annals of Internal Medicine. Vol. 10, Pg. 1874, 1937.