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Substance Name: Tyramine hydrochloride
RN: 60-19-5
UNII: Z5KDH3H147
InChIKey: RNISDHSYKZAWOK-UHFFFAOYSA-N

Note

  • An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.

Molecular Formula

  • C8-H11-N-O.Cl-H

Molecular Weight

  • 173.642
 

Classification Codes

  • Adrenergic Uptake Inhibitors
  • Drug / Therapeutic Agent
  • Mutation Data
  • Sympathomimetics
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Names and Synonyms

Results Name

  • Tyramine hydrochloride

Name of Substance

  • Tyramine hydrochloride

Synonyms

  • 4-(2-Aminoethyl)phenol hydrochloride
  • 4-Hydroxyphenethylamine hydrochloride
  • AI3-52151
  • CCRIS 986
  • EINECS 200-462-5
  • NSC 27430
  • p-Tryamine hydrochloride
  • p-Tyramine hydrochloride
  • Phenol, p-(2-aminoethyl)-, monochloride
  • Tyramine
  • Tyramine hydrochloride
  • Tyramine monochloride
  • Tyrosamine hydrochloride
  • UNII-Z5KDH3H147

Systematic Names

  • 4-Hydroxyphenethylammonium chloride
  • Phenol, 4-(2-aminoethyl)-, hydrochloride
  • Phenol, 4-(2-aminoethyl)-, hydrochloride (1:1)
  • Phenol, p-(2-aminoethyl)-, hydrochloride (8CI)
  • Phenol, p-(2-aminoethyl)-, monohydrochloride
  • Tyramine hydrochloride

Registry Numbers

CAS Registry Number

  • 60-19-5

FDA UNII

  • Z5KDH3H147

System Generated Number

  • 0000060195

Molecular Formulas

Molecular Formula

  • C8-H11-N-O.Cl-H

Molecular Formula Fragments

  • C8-H11-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C8H11NO.ClH/c9-6-5-7-1-3-8(10)4-2-7;/h1-4,10H,5-6,9H2;1H

InChIKey

RNISDHSYKZAWOK-UHFFFAOYSA-N

Smiles

c1cc(CCN)ccc1O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo subcutaneous 1044mg/kg (1044mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Journal of Pharmacology and Experimental Therapeutics. Vol. 47, Pg. 339, 1933.
mouse LD50 intraperitoneal 710mg/kg (710mg/kg)   Toxicology and Applied Pharmacology. Vol. 28, Pg. 227, 1974.
mouse LD50 intravenous 208mg/kg (208mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
European Journal of Pharmacology. Vol. 9, Pg. 289, 1970.
mouse LDLo unreported 2750mg/kg (2750mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 8, Pg. 126, 1916.