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Substance Name: Ether [USP:JAN]
RN: 60-29-7
UNII: 0F5N573A2Y
InChIKey: RTZKZFJDLAIYFH-UHFFFAOYSA-N

Note

  • A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.

Molecular Formula

  • C4-H10-O

Molecular Weight

  • 74.122
 

Classification Codes

Classification Codes

  • Anesthetic (Inhalation)
  • Anesthetics
  • Anesthetics, General
  • Anesthetics, Inhalation
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Skin / Eye Irritant
  • Solvents
  • Tumor Data

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 255
  • 2011 CERCLA Priority List, Rank: 252
  • Reportable Quantity (RQ) = 100 lb
  • TWA (400 ppm); STEL (500 ppm)
  • TWA 400 ppm (1200 mg/m3)

Names and Synonyms

Name of Substance

  • Diethyl ether
  • Ether [USP:JAN]
  • Ether, ethyl

MeSH Heading

  • Ether

Synonyms

  • 1,1'-Oxybisethane
  • 3-Oxapentane
  • Aether
  • AI3-24233
  • Anaesthetic ether
  • Anesthesia ether
  • Anesthetic ether
  • Anhydrous ether
  • Diaethylaether
  • Diaethylaether [German]
  • Diethyl oxide
  • Dwuetylowy eter
  • Dwuetylowy eter [Polish]
  • EC 200-467-2
  • EINECS 200-467-2
  • Etere etilico
  • Etere etilico [Italian]
  • Ethane, 1,1'-oxybis-
  • Ether
  • Ether anhydrous
  • Ether ethylique
  • Ether ethylique [French]
  • Ether, anhydrous
  • Ether, ethyl
  • Ethoxyethane
  • Ethyl ether
  • Ethyl ether, tech.
  • Ethyl oxide
  • HSDB 70
  • NSC 100036
  • Oxyde d'ethyle
  • Oxyde d'ethyle [French]
  • Pronarcol
  • RCRA waste number U117
  • Solvent ether
  • UNII-0F5N573A2Y

Systematic Names

  • Diethyl ether
  • Ethane, 1,1'-oxybis-
  • Ethyl ether (8CI)

Superlist Names

  • Diethyl ether
  • Diethyl ether or ethyl ether
  • Diethyl ether or ethyl ether [UN1155] [Flammable liquid]
  • Diethyl ether [Anaesthetics, volatile]
  • Ethane, 1,1'-oxybis-
  • Ether
  • Ethyl ether
  • RCRA waste no. U117
  • UN1155

Registry Numbers

CAS Registry Number

  • 60-29-7

FDA UNII

  • 0F5N573A2Y

Other Registry Numbers

  • 74446-43-8
  • 7578-39-4
  • 927820-24-4

System Generated Number

  • 0000060297

Structure Descriptors

InChI

1S/C4H10O/c1-3-5-4-2/h3-4H2,1-2H3

InChIKey

RTZKZFJDLAIYFH-UHFFFAOYSA-N

Smiles

O(CC)CC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LCLo inhalation 76000ppm (76000ppm)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1294, 1935.
frog LDLo subcutaneous 24gm/kg (24000mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1295, 1935.
guinea pig LDLo intraperitoneal 2gm/kg (2000mg/kg)   American Industrial Hygiene Association Journal. Vol. 35, Pg. 21, 1974.
human TCLo inhalation 200ppm (200ppm) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 282, 1943.
man LDLo oral 260mg/kg (260mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse LC50 inhalation 31000ppm/30M (31000ppm) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Experimental Animals. Jikken Dobutso Iho. Vol. 34, Pg. 379, 1985.
mouse LD50 intraperitoneal 2420mg/kg (2420mg/kg)   Proceedings of the Western Pharmacology Society. Vol. 27, Pg. 511, 1984.
mouse LD50 intravenous 996mg/kg (996mg/kg)   Journal of Pharmaceutical Sciences. Vol. 67, Pg. 566, 1978.
mouse LDLo subcutaneous 8mg/kg (8mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1295, 1935.
rabbit LCLo inhalation 106000ppm (106000ppm)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1294, 1935.
rabbit LD50 skin > 20mL/kg (20mL/kg)   American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.
rat LCLo inhalation 32000ppm/4H (32000ppm)   American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.
rat LD50 oral 1215mg/kg (1215mg/kg)   Toxicology and Applied Pharmacology. Vol. 19, Pg. 699, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -1.16E+02 deg C   EXP
Boiling Point 34.5 deg C   EXP
pKa Dissociation Constant -3.59E+00 (none)   EXP
log P (octanol-water) 0.89 (none)   EXP
Water Solubility 6.04E+04 mg/L 25 EXP
Vapor Pressure 538 mm Hg 25 EXP
Henry's Law Constant 0.00123 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 1.31E-11 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.