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Substance Name: Acetamide
RN: 60-35-5
UNII: 8XOE1JSO29
InChIKey: DLFVBJFMPXGRIB-UHFFFAOYSA-N

Molecular Formula

  • C2-H5-N-O

Molecular Weight

  • 59.0675
 

Classification Codes

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect
  • Tumor Data

Superlist Classification Codes

  • Overall Carcinogenic Evaluation: Group 2B
  • Reportable Quantity (RQ) = 100 lb

Names and Synonyms

Name of Substance

  • Acetamide

Synonyms

  • 4-02-00-00399 (Beilstein Handbook Reference)
  • Acetamide
  • Acetic acid amide
  • Acetimidic acid
  • Acetimidic acid (VAN)
  • AI3-02060
  • Amid kyseliny octove
  • Amid kyseliny octove [Czech]
  • BRN 1071207
  • Caswell No. 003H
  • CCRIS 2
  • EC 200-473-5
  • EINECS 200-473-5
  • Ethanamide
  • HSDB 4006
  • Methanecarboxamide
  • NCI-C02108
  • NSC 25945
  • UNII-8XOE1JSO29

Systematic Name

  • Acetamide

Superlist Name

  • Acetamide

Registry Numbers

CAS Registry Number

  • 60-35-5

FDA UNII

  • 8XOE1JSO29

System Generated Number

  • 0000060355

Structure Descriptors

InChI

1S/C2H5NO/c1-2(3)4/h1H3,(H2,3,4)

InChIKey

DLFVBJFMPXGRIB-UHFFFAOYSA-N

Smiles

C(=O)(C)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LDLo intravenous 33410mg/kg (33410mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1242, 1970.
mouse LD50 intraperitoneal 1gm/kg (1000mg/kg)   JNCI, Journal of the National Cancer Institute. Vol. 62, Pg. 911, 1979.
mouse LD50 intravenous 10gm/kg (10000mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64(1), Pg. 42S, 1968.
mouse LD50 oral 12900mg/kg (12900mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64(1), Pg. 42S, 1968.
mouse LD50 subcutaneous 8300mg/kg (8300mg/kg) AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"

CARDIAC: CHANGE IN RATE

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 451, 1970.
rabbit LD50 intravenous 7500mg/kg (7500mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64(1), Pg. 42S, 1968.
rat LD50 intraperitoneal 10300mg/kg (10300mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1242, 1970.
rat LD50 intravenous 12500mg/kg (12500mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64(1), Pg. 42S, 1968.
rat LD50 oral 7gm/kg (7000mg/kg)   Journal of Reproduction and Fertility. Vol. 4, Pg. 219, 1962.
rat LD50 subcutaneous 10gm/kg (10000mg/kg) AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

CARDIAC: CHANGE IN RATE
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 451, 1970.
rat LD50 unreported 2300mg/kg (2300mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 645, 1968.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 81 deg C   EXP
Boiling Point 222 deg C   EXP
pKa Dissociation Constant 0.63 (none)   EXP
log P (octanol-water) -1.26E+00 (none)   EXP
Water Solubility 2.25E+06 mg/L 25 EXP
Henry's Law Constant 1.12E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.10E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.