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Substance Name: Mecamylamine [INN:BAN]
RN: 60-40-2
InChIKey: IMYZQPCYWPFTAG-UHFFFAOYSA-N
Note
- A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Molecular Formula
- C11-H21-N
Molecular Weight
- 167.2939
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antihypertensive Agents
- Autonomic Agents
- Cardiovascular Agents
- Cholinergic Agents
- Cholinergic Antagonists
- Drug / Therapeutic Agent
- Ganglionic Blockers
- Neurotransmitter Agents
- Nicotinic Antagonists
- Peripheral Nervous System Agents
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Links to Resources
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Names and Synonyms
Name of Substance
- Mecamylamine
- Mecamylamine [INN:BAN]
MeSH Heading
- Mecamylamine
Synonyms
- 2-Methylamino-2,3,3-trimethylnorbornane
- 2-Methylaminoisocamphane
- 3-beta-Methylamino-2,2,3-trimethylbicyclo(2.2.1)heptane
- 3-Methylaminoisocamphane
- 3-Methylaminoisokamfan
- 3-Methylaminoisokamfan [Czech]
- EINECS 200-476-1
- Mecamilamina
- Mecamilamina [DCIT]
- Mecamilamina [Italian]
- Mecamine
- Mecamylamine
- Mecamylaminum
- Mecamylaminum [INN-Latin]
- Mekamine
- Mevasine
- N,2,3,3-Tetramethyl-2-norbornamine
- N,2,3,3-Tetramethyl-2-norcamphanamine
- N-Methyl-2-isocamphanamine
- Revertina
- Versamine
Systematic Names
- 2-Norbornanamine, N,2,3,3-tetramethyl-
- Bicyclo(2.2.1)heptan-2-amine, N,2,3,3-tetramethyl-
- Mecamylamine
Registry Numbers
CAS Registry Number
- 60-40-2
System Generated Number
- 0000060402
Structure Descriptors
InChI
1S/C11H21N/c1-10(2)8-5-6-9(7-8)11(10,3)12-4/h8-9,12H,5-7H2,1-4H3InChIKey
IMYZQPCYWPFTAG-UHFFFAOYSA-NSmiles
CNC1(C)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 40mg/kg (40mg/kg) | BEHAVIORAL: SLEEP | Archivum Immunologiae et Therapiae Experimentalis. Vol. 10, Pg. 905, 1962. |
| mouse | LD50 | intravenous | 11900ug/kg (11.9mg/kg) | United States Patent Document. Vol. #4168308, | |
| mouse | LD50 | oral | 90mg/kg (90mg/kg) | Bollettino Chimico Farmaceutico. Vol. 103, Pg. 490, 1964. | |
| mouse | LD50 | subcutaneous | 37500ug/kg (37.5mg/kg) | Farmakologiya i Toksikologiya Vol. 25, Pg. 163, 1962. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | < 25 | deg C | EXP | |
| log P (octanol-water) | 3.310 | (none) | EST | |
| Atmospheric OH Rate Constant | 7.01E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.