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Substance Name: Strychnine sulfate [NF]
RN: 60-41-3
UNII: FA486DV76S
InChIKey: GOOCRIHPADOQAS-ZNUXJMJHSA-N

Note

  • An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.

Molecular Formula

  • C21-H22-N2-O2.1/2H2-O4-S

Molecular Weight

  • 766.9114
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Drug / Therapeutic Agent
  • Human Data
  • Rodenticide

Superlist Classification Code

  • Threshold Planning Quantity (TPQ) = 100/10000 lb
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Names and Synonyms

Name of Substance

  • Strychnine sulfate [NF]

Synonyms

  • Antivampire
  • Caswell No. 806
  • EINECS 200-477-7
  • EPA Pesticide Chemical Code 076902
  • Strychinium sulfate
  • Strychnine sulfate
  • UNII-FA486DV76S
  • Vampirol

Systematic Names

  • Strychnidin-10-one, sulfate (2:1)
  • Strychnidin-10-one, sulfate (2:1) (9CI)
  • Strychnine sulphate
  • Strychnine, sulfate (2:1)

Superlist Names

  • Strychnine sulfate
  • Strychnine, sulfate

Registry Numbers

CAS Registry Number

  • 60-41-3

FDA UNII

  • FA486DV76S

System Generated Number

  • 0000060413

Molecular Formulas

Molecular Formula

  • C21-H22-N2-O2.1/2H2-O4-S

Molecular Formula Fragments

  • C21-H22-N2-O2
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/2C21H22N2O2.H2O4S/c2*24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;1-5(2,3)4/h2*1-5,13,16-17,19-20H,6-11H2;(H2,1,2,3,4)/t2*13-,16-,17-,19-,20-,21+;/m00./s1

InChIKey

GOOCRIHPADOQAS-ZNUXJMJHSA-N

Smiles

c1ccc2c(c1)[C@]34CC[N@@]5[C@H]3C[C@@H]6[C@@H]7[C@@H]4N2C(=O)C[C@@H]7OCC=C6C5.c1ccc2c(c1)[C@]34CC[N@@]5[C@H]3C[C@@H]6[C@@H]7[C@@H]4N2C(=O)C[C@@H]7OCC=C6C5.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 5600ug/kg (5.6mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
cat LD50 intravenous 2500ug/kg (2.5mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 35, Pg. 316, 1936.
child LDLo oral 3367ug/kg (3.367mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Journal of Forensic Sciences. Vol. 30, Pg. 1248, 1985.
guinea pig LD50 intraperitoneal 10900ug/kg (10.9mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives Internationales de Pharmacodynamie et de Therapie. Vol. 144, Pg. 416, 1963.
guinea pig LD50 intravenous 390ug/kg (0.39mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives Internationales de Pharmacodynamie et de Therapie. Vol. 144, Pg. 416, 1963.
guinea pig LD50 subcutaneous 4800ug/kg (4.8mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives Internationales de Pharmacodynamie et de Therapie. Vol. 144, Pg. 416, 1963.
man LDLo oral 37mg/kg (37mg/kg) CARDIAC: PULSE RATE

LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Analytical Toxicology. Vol. 10, Pg. 120, 1986.
mouse LD50 intraperitoneal 900ug/kg (0.9mg/kg)   International Journal for Vitamin and Nutrition Research, Supplement. Vol. 16, Pg. 31, 1977.
mouse LD50 intravenous 475ug/kg (0.475mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 79, Pg. 127, 1943.
mouse LD50 subcutaneous 1250ug/kg (1.25mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 67, Pg. 153, 1939.
mouse LDLo oral 8mg/kg (8mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 14, Pg. 111, 1985.
rat LD50 intraperitoneal 1mg/kg (1mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 1125, 1973.
rat LD50 intravenous 570ug/kg (0.57mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives Internationales de Pharmacodynamie et de Therapie. Vol. 144, Pg. 416, 1963.
rat LD50 oral 2600ug/kg (2.6mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 31, Pg. 113, 1942.
rat LD50 subcutaneous 1700ug/kg (1.7mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
women TDLo oral 6800ug/kg (6.8mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BLOOD: OTHER CHANGES
Canadian Medical Association Journal. Vol. 124, Pg. 1268, 1981.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 200 dec deg C   EXP
Water Solubility 3.00E+04 mg/L   EXP

Physical property data is provided to ChemIDplus by SRC, Inc.