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Substance Name: Diethazine [INN:BAN]
RN: 60-91-3
UNII: 28B5CG0RU3
InChIKey: LURMIKVZJSMXQE-UHFFFAOYSA-N

Note

  • Phenothiazine derivative anti-Parkinson agent with anticholinergic and antihistaminic actions; is effective against Parkinson tremor.

Molecular Formula

  • C18-H22-N2-S

Molecular Weight

  • 298.4518
 
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Names and Synonyms

Name of Substance

  • Diethazine
  • Diethazine [INN:BAN]

Synonyms

  • 10-(2-Diethylaminoethyl)phenothiazine
  • Casantin
  • Casantin [German]
  • Diaethazinum
  • Dietazina
  • Dietazina [INN-Spanish]
  • Diethazine
  • Diethazinum
  • Diethazinum [INN-Latin]
  • Dolisina
  • Eazamine
  • EINECS 200-491-3
  • Fourneau 2987
  • Lodibon
  • N-(2'-Diethylaminoethyl)dibenzoparathiazine
  • N-(Diethylaminoethyl)thiodiphenylamine
  • UNII-28B5CG0RU3

Systematic Names

  • 10H-Phenothiazine-10-ethanamine, N,N-diethyl- (9CI)
  • Diethazine
  • Phenothiazine, 10-(2-(diethylamino)ethyl)-

Registry Numbers

CAS Registry Number

  • 60-91-3

FDA UNII

  • 28B5CG0RU3

Related Registry Number

  • 341-70-8 (mono-hydrochloride)

System Generated Number

  • 0000060913

Structure Descriptors

InChI

1S/C18H22N2S/c1-3-19(4-2)13-14-20-15-9-5-7-11-17(15)21-18-12-8-6-10-16(18)20/h5-12H,3-4,13-14H2,1-2H3

InChIKey

LURMIKVZJSMXQE-UHFFFAOYSA-N

Smiles

CCN(CC)CCN1c2ccccc2Sc3c1cccc3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 225mg/kg (225mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 171, 1954.
mouse LD50 intravenous 56mg/kg (56mg/kg)   Helvetica Physiologia et Pharmacologica Acta. Vol. 16, Pg. 277, 1958.
mouse LD50 oral 450mg/kg (450mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: REGIDITY
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 134, Pg. 255, 1961.
mouse LD50 subcutaneous 450mg/kg (450mg/kg)   Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963.
rabbit LD50 intravenous 20mg/kg (20mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 450, 1959.
rat LD50 intravenous 28500ug/kg (28.5mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 103, Pg. 371, 1955.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point < 25 deg C   EXP
log P (octanol-water) 5.94 (none)   EXP
Water Solubility 0.053 mg/L 25 EST
Vapor Pressure 7.53E-08 mm Hg 25 EST
Henry's Law Constant 4.89E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.58E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.