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Substance Name: Cetylpyridinium chloride [USP:INN:BAN:JAN]
RN: 6004-24-6
UNII: D9OM4SK49P
InChIKey: NFCRBQADEGXVDL-UHFFFAOYSA-M

Note

  • Cationic bactericidal surfactant used as a topical antiseptic for skin, wounds, mucous membranes, instruments, etc.; and also as a component in mouthwash and lozenges.

Molecular Formula

  • C21-H38-N.Cl.H2-O

Molecular Weight

  • 358.006
 

Classification Codes

  • Anti-Infective, Topical
  • Drug / Therapeutic Agent
  • Pharmaceutic Aid (Preservative)
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Names and Synonyms

Name of Substance

  • Cetylpyridinium chloride [USP:INN:BAN:JAN]

Synonyms

  • 1-Hexadecylpyridinium chloride monohydrate
  • Ceepryn
  • Cepacol
  • Cetylpyridinium chloride
  • Cetylpyridinium chloride monohydrate
  • NSC 756673
  • UNII-D9OM4SK49P

Systematic Name

  • Pyridinium, 1-hexadecyl-, chloride, monohydrate

Registry Numbers

CAS Registry Number

  • 6004-24-6

FDA UNII

  • D9OM4SK49P

System Generated Number

  • 0006004246

Molecular Formulas

Molecular Formula

  • C21-H38-N.Cl.H2-O

Molecular Formula Fragments

  • C21-H38-N
  • Cl
  • COMPONENT
  • H2-O

Structure Descriptors

InChI

InChI=1S/C21H38N.ClH.H2O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-22-20-17-15-18-21-22;;/h15,17-18,20-21H,2-14,16,19H2,1H3;1H;1H2/q+1;;/p-1

InChIKey

NFCRBQADEGXVDL-UHFFFAOYSA-M

Smiles

O.[Cl-].CCCCCCCCCCCCCCCC[n+]1ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 100mg/kg (100mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 401, 1942.
guinea pig LDLo intraperitoneal 5mg/kg (5mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 401, 1942.
mouse LDLo intraperitoneal 3mg/kg (3mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 401, 1942.
rabbit LDLo intraperitoneal 5mg/kg (5mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 401, 1942.
rabbit LDLo intravenous 20mg/kg (20mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 401, 1942.
rabbit LDLo oral 400mg/kg (400mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 401, 1942.
rabbit LDLo subcutaneous 200mg/kg (200mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 401, 1942.
rat LDLo intraperitoneal 15mg/kg (15mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 401, 1942.