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Substance Name: Tiazofurin [USAN]
RN: 60084-10-8
UNII: ULJ82834RE
InChIKey: FVRDYQYEVDDKCR-DBRKOABJSA-N

Molecular Formula

  • C9-H12-N2-O5-S

Molecular Weight

  • 260.2688
 

Classification Codes

  • Antimetabolites
  • Antimetabolites, Antineoplastic
  • Antineoplastic
  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Noxae
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Tiazofurin
  • Tiazofurin [USAN]
  • Tiazofurine [INN]

Synonyms

  • 2-beta-D-Ribofuranosyl-4-thiazolecarboxamide
  • BRN 1084555
  • CI-909
  • NSC 286193
  • NSC-286193
  • Riboxamide
  • Tiazofurin
  • Tiazofurina
  • Tiazofurina [Spanish]
  • Tiazofurine
  • Tiazofurinum
  • Tiazofurinum [Latin]
  • UNII-ULJ82834RE

Systematic Name

  • 4-Thiazolecarboxamide, 2-beta-D-ribofuranosyl-

Registry Numbers

CAS Registry Number

  • 60084-10-8

FDA UNII

  • ULJ82834RE

System Generated Number

  • 0060084108

Structure Descriptors

InChI

1S/C9H12N2O5S/c10-8(15)3-2-17-9(11-3)7-6(14)5(13)4(1-12)16-7/h2,4-7,12-14H,1H2,(H2,10,15)/t4-,5-,6-,7-/m1/s1

InChIKey

FVRDYQYEVDDKCR-DBRKOABJSA-N

Smiles

NC(=O)c1csc(n1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 1090mg/kg (1090mg/kg) BEHAVIORAL: FLUID INTAKE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: FOOD INTAKE (ANIMAL)
National Technical Information Service. Vol. PB83-156901,
human TDLo intravenous 892mg/kg/10D- (892mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Cancer Research. Vol. 45, Pg. 5169, 1985.
human TDLo intravenous 1135mg/kg/15D (1135mg/kg) BEHAVIORAL: HEADACHE

MUSCULOSKELETAL: OTHER CHANGES
Cancer Research. Vol. 45, Pg. 5169, 1985.
mouse LD50 intraperitoneal 1684mg/kg (1684mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse LD50 intravenous 3400mg/kg (3400mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BLOOD: OTHER CHANGES
National Technical Information Service. Vol. PB83-156901,
rat LDLo intraperitoneal 1gm/kg (1000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE
Toxicology Letters. Vol. 114, Pg. 81, 2000.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -1.73E+00 (none)   EXP
Water Solubility 3.05E+04 mg/L 25 EST
Vapor Pressure 2.19E-13 mm Hg 25 EST
Henry's Law Constant 1.29E-22 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 4.11E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.