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Substance Name: Nocardicin B
RN: 60134-71-6
UNII: QWV6T6M34F
InChIKey: CTNZOGJNVIFEBA-TWTPMLPMSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C23-H24-N4-O9

Molecular Weight

  • 500.4616
 
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Names and Synonyms

Name of Substance

  • Nocardicin B

Synonyms

  • Antibiotic FR 2458
  • BRN 3599648
  • FR-2458
  • Nocardicin B
  • UNII-QWV6T6M34F

Systematic Name

  • 1-Azetidineacetic acid, 3-(((4-(3-amino-3-carboxypropoxy)phenyl)(hydroxyimino)acetyl)amino)-alpha-(4-hydroxyphenyl)-2-oxo-, (3S-(1(S*),3R*(E(S*))))-

Registry Numbers

CAS Registry Number

  • 60134-71-6

FDA UNII

  • QWV6T6M34F

System Generated Number

  • 0060134716

Structure Descriptors

InChI

1S/C23H24N4O9/c24-16(22(31)32)9-10-36-15-7-3-12(4-8-15)18(26-35)20(29)25-17-11-27(21(17)30)19(23(33)34)13-1-5-14(28)6-2-13/h1-8,16-17,19,28,35H,9-11,24H2,(H,25,29)(H,31,32)(H,33,34)/b26-18+/t16-,17+,19-/m1/s1

InChIKey

CTNZOGJNVIFEBA-TWTPMLPMSA-N

Smiles

c1cc(ccc1[C@H](C(=O)O)N2C[C@@H](C2=O)NC(=O)/C(=N/O)/c3ccc(cc3)OCC[C@H](C(=O)O)N)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD intraperitoneal > 750mg/kg (750mg/kg)   Journal of Antibiotics. Vol. 29, Pg. 1243, 1976.
mouse LD subcutaneous > 750mg/kg (750mg/kg)   Journal of Antibiotics. Vol. 29, Pg. 1243, 1976.
mouse LD50 intravenous 250mg/kg (250mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 116, 1980.
mouse LD50 oral 1gm/kg (1000mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 116, 1980.