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Substance Name: Thiocolchicoside [INN:DCF]
RN: 602-41-5
UNII: T1X8S697GT
InChIKey: LEQAKWQJCITZNK-AXHKHJLKSA-N

Note

  • Used in combination with glafenine and meprobamate to tranquilize patients undergoing hysterosalpingography.

Molecular Formula

  • C27-H33-N-O10-S

Molecular Weight

  • 563.6207
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Thiocolchicoside
  • Thiocolchicoside [INN:DCF]

Synonyms

  • 10-Thiocolchicoside
  • 2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine
  • 4-17-00-03428 (Beilstein Handbook Reference)
  • BRN 0072205
  • Colchicoside, 10-thio-
  • Coltramyl
  • EINECS 210-017-7
  • Musco-ril
  • NSC 147755
  • R. 271
  • Thiocolchicine 2-glucoside analog
  • Thiocolchicoside
  • Thiocolchicosidum
  • Thiocolchicosidum [INN-Latin]
  • Tiocolchicoside
  • Tiocolchicoside [DCIT]
  • Tiocolchicosido
  • Tiocolchicosido [INN-Spanish]
  • UNII-T1X8S697GT

Systematic Names

  • 2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine
  • Acetamide, N-(3-(beta-D-glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo(a)heptalen-7-yl)-, (S)-
  • Colchicoside, 10-thio- (8CI)
  • Thiocolchicoside

Registry Numbers

CAS Registry Number

  • 602-41-5

FDA UNII

  • T1X8S697GT

System Generated Number

  • 0000602415

Structure Descriptors

InChI

1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,19+,22+,23-,24+,27+/m0/s1

InChIKey

LEQAKWQJCITZNK-AXHKHJLKSA-N

Smiles

COc1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc3CC[C@H](NC(=O)C)C4=CC(=O)C(=CC=C4c3c1OC)SC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1mg/kg (1mg/kg)   Farmaco, Edizione Scientifica. Vol. 15, Pg. 533, 1960.
rat LD50 intramuscular 27500ug/kg (27.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

BEHAVIORAL: EXCITEMENT
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 109, Pg. 386, 1957.
rat LD50 intravenous 10mg/kg (10mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 109, Pg. 386, 1957.
rat LDLo intracrebral 1ug/kg (0.001mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 109, Pg. 386, 1957.
rat LDLo parenteral 1ug/kg (0.001mg/kg)   Farmaco, Edizione Scientifica. Vol. 15, Pg. 533, 1960.