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Substance Name: Homidium chloride
RN: 602-52-8
UNII: 7XPK80D0XV
InChIKey: BITVSRNAFFZUFW-UHFFFAOYSA-N

Note

  • /Ethidium/ A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.

Molecular Formula

  • C21-H20-N3.Cl

Molecular Weight

  • 349.863
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Results Name

  • Homidium chloride

Name of Substance

  • Homidium chloride

Synonyms

  • 2,7-Diamino-9-phenyl-10-ethylphenanthridinium chloride
  • 3,8-Diamino-5-ethyl-6-phenylphenanthridinium chloride
  • Babidium chloride
  • EINECS 210-018-2
  • Ethidium chloride
  • Homidium chloride
  • Novidium chloride
  • NSC 522843
  • NSC-84423
  • Phenanthridinium, 3,8-diamino-5-ethyl-6-phenyl chloride
  • UNII-7XPK80D0XV

Systematic Names

  • 3,8-Diamino-5-ethyl-6-phenylphenanthridinium chloride
  • Phenanthridinium, 3,8-diamino-5-ethyl-6-phenyl-, chloride

Registry Numbers

CAS Registry Number

  • 602-52-8

FDA UNII

  • 7XPK80D0XV

System Generated Number

  • 0000602528

Molecular Formulas

Molecular Formula

  • C21-H20-N3.Cl

Molecular Formula Fragments

  • C21-H20-N3
  • Cl
  • COMPONENT

Structure Descriptors

InChI

1S/C21H19N3.ClH/c1-2-24-20-13-16(23)9-11-18(20)17-10-8-15(22)12-19(17)21(24)14-6-4-3-5-7-14;/h3-13,23H,2,22H2,1H3;1H

InChIKey

BITVSRNAFFZUFW-UHFFFAOYSA-N

Smiles

c1(c2c(c3ccc(cc3[n+]1CC)N)ccc(c2)N)c1ccccc1.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 14mg/kg (14mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
National Cancer Institute Report. Vol. -, Pg. 107, 1965.
mouse LD50 oral > 1gm/kg (1000mg/kg)   National Cancer Institute Report. Vol. -, Pg. 107, 1965.
mouse LD50 subcutaneous 56370ug/kg (56.37mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
rat LD50 intravenous 21mg/kg (21mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
National Cancer Institute Report. Vol. -, Pg. 107, 1965.