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Substance Name: Racemethorphan hydrobromide
RN: 6031-86-3
UNII: 131YWR720Z
InChIKey: MISZALMBODQYFT-FLCXFYETSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C18-H25-N-O.Br-H

Molecular Weight

  • 352.313
 
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Names and Synonyms

Name of Substance

  • Racemethorphan hydrobromide

Synonyms

  • (+-)-3-Methoxy-17-methylmorphinan hydrobromide
  • Racemethorphan hydrobromide
  • Ro 1-5470
  • UNII-131YWR720Z

Systematic Name

  • Morphinan, 3-methoxy-17-methyl-, hydrobromide, (+-)-

Registry Numbers

CAS Registry Number

  • 6031-86-3

FDA UNII

  • 131YWR720Z

System Generated Number

  • 0006031863

Molecular Formulas

Molecular Formula

  • C18-H25-N-O.Br-H

Molecular Formula Fragments

  • Br-H
  • C18-H25-N-O
  • COMPONENT

Structure Descriptors

InChI

1S/C18H25NO.BrH/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18;/h6-7,12,15,17H,3-5,8-11H2,1-2H3;1H/t15-,17+,18+;/m0./s1

InChIKey

MISZALMBODQYFT-FLCXFYETSA-N

Smiles

c1(ccc2c(c1)[C@]13CCCC[C@H]3[C@@H]([N@](CC1)C)C2)OC.Br

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 27mg/kg (27mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.
mouse LD50 oral 175mg/kg (175mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.
mouse LD50 subcutaneous 160mg/kg (160mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.
rabbit LD50 intravenous 16700ug/kg (16.7mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: REGIDITY
Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.
rat LD50 oral 235mg/kg (235mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: REGIDITY
Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.
rat LD50 subcutaneous 165mg/kg (165mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: REGIDITY
Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.