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Substance Name: Trichosanthins
RN: 60318-52-7


  • Plant-derived ribosome-inactivating protein (RIP) purified from the Chinese medicinal herb tian-hua-fen which is obtained from the root tubers of Trichosanthes kirilowii. It has been used as an abortifacient and in the treatment of trophoblastic tumors. GLQ223 (Compound Q), a highly purified form of trichosanthin, has been proposed as antiviral treatment for AIDS.

Molecular Formula

  • Unspecified

Classification Codes

  • Abortifacient
  • Abortifacient Agents
  • Abortifacient Agents, Nonsteroidal
  • Anti-HIV Agents
  • Anti-Infective Agents
  • Anti-Retroviral Agents
  • Antineoplastic
  • Antineoplastic Agents
  • Antineoplastic Agents, Phytogenic
  • Antiretroviral
  • Antiviral Agents
  • Immunosuppressant
  • Natural Product
  • Reproductive Control Agents
  • Reproductive Effect
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Links to Resources

Names and Synonyms

Results Name

  • Trichosanthins

Name of Substance

  • Trichosanthin

MeSH Heading

  • Trichosanthin


  • alpha-Trichosanthin
  • Compound Q
  • GLQ-223
  • GLQ223
  • NSC 614853
  • Proteins, specific or class, trichosantins
  • T'ien-hua-fen
  • Tian-hua-fen
  • Trichosanthin

Systematic Name

  • Tricosanthin

Registry Numbers

CAS Registry Number

  • 60318-52-7

Other Registry Numbers

  • 120367-43-3
  • 88026-75-9

System Generated Number

  • 0060318527


Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 subcutaneous 5900ug/kg (5.9mg/kg)   "Zhongliu Yanjiu" Cancer Review, Yu, R., et al., eds., Shanghai Science/Technology Publisher,Peop. Rep. China, 1994Vol. -, Pg. 197, 1994.