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Substance Name: Oxatomide [USAN:INN:BAN:JAN]
RN: 60607-34-3
UNII: J31IL9Z2EE
InChIKey: BAINIUMDFURPJM-UHFFFAOYSA-N

Note

  • An anti-allergic & an anti-asthmatic.

Molecular Formula

  • C27-H30-N4-O

Molecular Weight

  • 426.561
 

Classification Codes

  • Anti-Allergic
  • Anti-Allergic Agents
  • Anti-Asthmatic
  • Anti-Asthmatic Agents
  • Drug / Therapeutic Agent
  • Histamine Agents
  • Histamine Antagonists
  • Histamine H1 Antagonists
  • Neurotransmitter Agents
  • Reproductive Effect
  • Respiratory System Agents
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Names and Synonyms

Name of Substance

  • Oxatomide
  • Oxatomide [USAN:INN:BAN:JAN]

Synonyms

  • 1-(3-(4-(Diphenylmethyl)-1-piperazinyl)propyl)-1,3-dihydro-2H-benzimidazol-2-one
  • 1-(3-(4-(Diphenylmethyl)-1-piperazinyl)propyl)-2-benzimidazolinone
  • 2H-Benzimidazol-2-one, 1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-1,3-dihydro-
  • BRN 4724760
  • EINECS 262-320-9
  • KW-4354
  • McN-JR 35443
  • Oxatimide
  • Oxatomida
  • Oxatomida [INN-Spanish]
  • Oxatomide
  • Oxatomidum
  • Oxatomidum [INN-Latin]
  • Oxetal
  • R 35,443
  • R 35443
  • Tinset
  • UNII-J31IL9Z2EE

Systematic Names

  • 1-(3-(4-(Diphenylmethyl)-1-piperazinyl)propyl)-1,3-dihydro-2H-benzimidazol-2-one
  • 2H-Benzimidazol-2-one, 1,3-dihydro-1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-
  • 2H-Benzimidazol-2-one, 1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-1,3-dihydro-
  • Oxatomide

Registry Numbers

CAS Registry Number

  • 60607-34-3

FDA UNII

  • J31IL9Z2EE

System Generated Number

  • 0060607343

Structure Descriptors

InChI

1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32)

InChIKey

BAINIUMDFURPJM-UHFFFAOYSA-N

Smiles

c1ccc(cc1)C(c2ccccc2)N3CCN(CC3)CCCn4c5ccccc5[nH]c4=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 2gm/kg (2000mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 2769, 1984.
guinea pig LD50 intravenous 23mg/kg (23mg/kg)   Drugs of the Future. Vol. 3, Pg. 465, 1978.
guinea pig LD50 oral 320mg/kg (320mg/kg)   Drugs of the Future. Vol. 3, Pg. 465, 1978.
mouse LD50 intraperitoneal 7926mg/kg (7926mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 2769, 1984.
mouse LD50 intravenous 25mg/kg (25mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 2769, 1984.
mouse LD50 oral 9596mg/kg (9596mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 2769, 1984.
mouse LD50 subcutaneous > 10125mg/kg (10125mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 2769, 1984.
rat LD50 intraperitoneal 63mg/kg (63mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 2769, 1984.
rat LD50 intravenous 29mg/kg (29mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 2769, 1984.
rat LD50 oral 1410mg/kg (1410mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 2769, 1984.
rat LD50 subcutaneous > 4500mg/kg (4500mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 2769, 1984.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 153.6 deg C   EXP
log P (octanol-water) 4.150 (none)   EST
Atmospheric OH Rate Constant 2.41E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.