Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Selumetinib [USAN:INN]
RN: 606143-52-6
UNII: 6UH91I579U
InChIKey: CYOHGALHFOKKQC-UHFFFAOYSA-N

Note

  • A MEK inhibitor.

    NCI: An orally bioavailable small molecule with potential antineoplastic activity. Selumetinib inhibits mitogen-activated protein kinase kinases (MEK or MAPK/ERK kinases) 1 and 2, which may prevent the activation of MEK1/2-dependent effector proteins and transcription factors, and so may inhibit cellular proliferation in MEK-overexpressing tumor cells. MEK 1 and 2 are dual-specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various tumor cell types, and are drivers of diverse cellular activities, including cellular proliferation. (NCI Thesaurus)

Molecular Formula

  • C17-H15-Br-Cl-F-N4-O3

Molecular Weight

  • 457.6855
 

Classification Code

  • Antineoplastic
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Selumetinib [USAN:INN]

Synonyms

  • ARRY 142886
  • ARRY-142886
  • AZD 6244
  • AZD6244
  • Selumetinib
  • UNII-6UH91I579U

Systematic Name

  • 1H-Benzimidazole-6-carboxamide, 5-((4-bromo-2-chlorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-

Registry Numbers

CAS Registry Number

  • 606143-52-6

FDA UNII

  • 6UH91I579U

Other Registry Number

  • 865610-79-3

System Generated Number

  • 0606143526

Structure Descriptors

InChI

1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

InChIKey

CYOHGALHFOKKQC-UHFFFAOYSA-N

Smiles

Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(cc12)C(=O)NOCCO