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Substance Name: Bifonazole [USAN:INN:BAN:JAN]
RN: 60628-96-8
UNII: QYJ305Z91O
InChIKey: OCAPBUJLXMYKEJ-UHFFFAOYSA-N

Classification Codes

  • Anti-Infective Agents
  • Antifungal
  • Antifungal Agents
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C22-H18-N2

Molecular Weight

  • 310.3982
 
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Names and Synonyms

Name of Substance

  • Bifonazole
  • Bifonazole [USAN:INN:BAN:JAN]

Synonyms

  • (+-)-1-(p,alpha-Diphenylbenzyl)imidazole
  • 1-((4-Biphenylyl)phenylmethyl)-1H-imidazole
  • 1-(alpha-(4-Biphenylyl)benzyl)imidazole
  • 1H-Imidazole, 1-((1,1'-biphenyl)-4-ylphenylmethyl)-
  • 1H-Imidazole, 1-((1,1'-biphenyl)-4-ylphenylmethyl)-, (+-)-
  • 5-23-04-00292 (Beilstein Handbook Reference)
  • BAY H 4502
  • Bifonazol
  • Bifonazol [INN-Spanish]
  • Bifonazole
  • Bifonazolum
  • Bifonazolum [INN-Latin]
  • BRN 0618427
  • EINECS 262-336-6
  • Mycospor
  • Trifonazole
  • UNII-QYJ305Z91O

Systematic Names

  • 1H-Imidazole, 1-((1,1'-biphenyl)-4-ylphenylmethyl)-, (+-)-
  • Bifonazole
  • Imidazole, 1-(alpha-(4-biphenylyl)benzyl)-

Registry Numbers

CAS Registry Number

  • 60628-96-8

FDA UNII

  • QYJ305Z91O

System Generated Number

  • 0060628968

Structure Descriptors

InChI

1S/C22H18N2/c1-3-7-18(8-4-1)19-11-13-21(14-12-19)22(24-16-15-23-17-24)20-9-5-2-6-10-20/h1-17,22H

InChIKey

OCAPBUJLXMYKEJ-UHFFFAOYSA-N

Smiles

c1ccc(cc1)c2ccc(cc2)C(c3ccccc3)n4ccnc4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 500mg/kg (500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 739, 1983.
mouse LD50 intravenous 57mg/kg (57mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 23, 1984.
mouse LD50 oral 2629mg/kg (2629mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 739, 1983.
mouse LD50 subcutaneous > 15gm/kg (15000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 23, 1984.
rabbit LD50 oral 4gm/kg (4000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 739, 1983.
rat LD50 intravenous 63mg/kg (63mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 23, 1984.
rat LD50 oral 1463mg/kg (1463mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 23, 1984.
rat LD50 subcutaneous > 10gm/kg (10000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 23, 1984.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 4.77 (none)   EXP
Water Solubility 0.110 mg/L 25 EST
Vapor Pressure 1.12E-10 mm Hg 25 EST
Henry's Law Constant 3.81E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 5.00E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.