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Substance Name: Inamrinone [USAN:USP]
RN: 60719-84-8
UNII: JUT23379TN
InChIKey: RNLQIBCLLYYYFJ-UHFFFAOYSA-N

Note

  • A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.

Molecular Formula

  • C10-H9-N3-O

Molecular Weight

  • 187.2011
 

Classification Codes

  • Calcium Channel Blockers
  • Cardiotonic
  • Cardiotonic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Human Data
  • Membrane Transport Modulators
  • Phosphodiesterase 3 Inhibitors
  • Phosphodiesterase Inhibitors
  • Protective Agents
  • Reproductive Effect
  • Vasodilator Agents

Names and Synonyms

Name of Substance

  • Amrinone
  • Amrinone [INN]
  • Inamrinone [USAN:USP]

MeSH Heading

  • Amrinone

Synonyms

  • (3,4'-Bipyridin)-6(1H)-one, 5-amino-
  • 3-Amino-5-(4-pyridinyl)-2(1H)-pyridinone
  • 5-25-15-00181 (Beilstein Handbook Reference)
  • 5-Amino(3,4'-bipyridin)-6(1H)-one
  • 5-Amino-(3,4'-bipyridin)-6(1H)-one
  • Amrinona
  • Amrinona [INN-Spanish]
  • Amrinone
  • Amrinonum
  • Amrinonum [INN-Latin]
  • AWD 08-250
  • BRN 0744819
  • CCRIS 3794
  • Cordemcura
  • EINECS 262-390-0
  • Inamrinone
  • Inocor
  • UNII-JUT23379TN
  • WIN 40680
  • Wincoram

Systematic Names

  • (3,4'-Bipyridin)-6(1H)-one, 5-amino-
  • Amrinone

Registry Numbers

CAS Registry Number

  • 60719-84-8

FDA UNII

  • JUT23379TN

System Generated Number

  • 0060719848

Structure Descriptors

InChI

1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)

InChIKey

RNLQIBCLLYYYFJ-UHFFFAOYSA-N

Smiles

c1cnccc1c2cc(c(=O)[nH]c2)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 3mg/kg/15M-I (3mg/kg) BLOOD: THROMBOCYTOPENIA Clinical Pharmacology and Therapeutics Vol. 53, Pg. 661, 1993.
dog LDLo intravenous 120mg/kg (120mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1117, 1990.
man LDLo oral 1429ug/kg (1.429mg/kg) BLOOD: THROMBOCYTOPENIA

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

LIVER: LIVER FUNCTION TESTS IMPAIRED
Archives of Internal Medicine. Vol. 145, Pg. 825, 1985.
mouse LD50 intravenous 150mg/kg (150mg/kg)   Trends in Pharmacological Sciences. Vol. 1, Pg. 143, 1980.
mouse LD50 oral 288mg/kg (288mg/kg)   Trends in Pharmacological Sciences. Vol. 1, Pg. 143, 1980.
mouse LD50 subcutaneous 212mg/kg (212mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1111, 1990.
rabbit LD50 oral 286mg/kg (286mg/kg)   Pharmazie. Vol. 41, Pg. 209, 1986.
rat LD50 intravenous 75mg/kg (75mg/kg)   Pharmazie. Vol. 41, Pg. 209, 1986.
rat LD50 oral 102mg/kg (102mg/kg)   New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 259, 1983.
rat LD50 subcutaneous 150mg/kg (150mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1111, 1990.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 295 dec deg C   EXP
log P (octanol-water) -0.350 (none)   EST
Atmospheric OH Rate Constant 5.96E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.