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Substance Name: (+)-Tetrandrine
RN: 518-34-3
UNII: 29EX23D5AJ
InChIKey: WVTKBKWTSCPRNU-KYJUHHDHSA-N

Note

  • A bisbenzylisoquinoline that exhibits antifibrogenic activity.

Molecular Formula

  • C38-H42-N2-O6

Molecular Weight

  • 622.7578
 

Classification Codes

  • Anti-Infective Agents
  • Antimalarials
  • Antineoplastic Agents
  • Antineoplastic Agents, Phytogenic
  • Antiparasitic Agents
  • Antiprotozoal Agents
  • Antiviral (COVID-19)
  • Antiviral Agents
  • Calcium Channel Blockers
  • Calcium-Regulating Hormones and Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Immunologic Factors
  • Immunosuppressive Agents
  • Membrane Transport Modulators
  • Mutation Data
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Names and Synonyms

Results Name

  • (+)-Tetrandrine

Name of Substance

  • Tetrandrine

Synonyms

  • (+)-Tetrandrine
  • (S,S)-Tetrandrine
  • 2-27-00-00889 (Beilstein Handbook Reference)
  • BRN 0877811
  • CCRIS 2705
  • D-Tetrandrine
  • Fanchinine
  • Hanjisong
  • NSC 77037
  • Sinomenine A
  • Tetrandrin
  • UNII-29EX23D5AJ

Systematic Names

  • Berbaman, 6,6',7,12-tetramethoxy-2,2'-dimethyl-, (1beta)-
  • Tetrandrine

Registry Numbers

CAS Registry Number

  • 518-34-3

FDA UNII

  • 29EX23D5AJ

Other Registry Numbers

  • 5990-67-0
  • 607379-81-7
  • 6490-80-8
  • 916770-74-6

System Generated Number

  • 0000518343

Structure Descriptors

InChI

InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1

InChIKey

WVTKBKWTSCPRNU-KYJUHHDHSA-N

Smiles

COc1ccc2C[C@@H]3N(C)CCc4cc(OC)c(OC)c(Oc5cc6[C@H](Cc7ccc(Oc1c2)cc7)N(C)CCc6cc5OC)c34

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 40mg/kg (40mg/kg) CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: TREMOR
Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 25, Pg. 610, 1994.
mouse LD50 intraperitoneal 41300ug/kg (41.3mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD "Zhongliu Yanjiu" Cancer Review, Yu, R., et al., eds., Shanghai Science/Technology Publisher,Peop. Rep. China, 1994Vol. -, Pg. 216, 1994.
mouse LD50 intravenous 37500ug/kg (37.5mg/kg)   Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 25, Pg. 39, 1990.
rabbit LDLo intravenous 15mg/kg (15mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

CARDIAC: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 25, Pg. 39, 1990.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 217.5 deg C   EXP
log P (octanol-water) 7.990 (none)   EST
Atmospheric OH Rate Constant 4.08E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.