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Substance Name: Cinnarizine clofibrate [INN]
RN: 60763-49-7
UNII: 8RJ419895I
InChIKey: GNQQJMWZCJAUJT-RSGUCCNWSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C26-H28-N2.C10-H11-Cl-O3

Molecular Weight

  • 583.168
 
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Names and Synonyms

Name of Substance

  • Cinnarizine clofibrate [INN]

Synonyms

  • (E)-1-Cinnamyl-(4-diphenylmethyl)-piperazin 2-(4-chlorphenoxy)-2-methylpropionat
  • (E)-4-Benzhydryl-1-cinnamylpiperazin 2-(4-chlorphenoxy)-2-methylpropionat
  • Cinnarizine clofibrate
  • Cinnarizini clofibras
  • Cinnarizini clofibras [INN-Latin]
  • Clofibrate de cinnarizine
  • Clofibrate de cinnarizine [INN-French]
  • Clofibrato de cinarizina
  • Clofibrato de cinarizina [INN-Spanish]
  • Clofibrato de cinarizina [Spanish]
  • LM 16
  • LM-16
  • UNII-8RJ419895I

Systematic Names

  • 2-(p-Chlorophenoxy)-2-methylpropionic acid compound with (E)-1-cinnamyl-4-(diphenylmethyl)piperazine (1:1)
  • Piperazine, (E)-1-cinnamyl-4-diphenylmethyl-, saltwith 2-(p-chlorophenoxy)-2-methylpropionic acid

Registry Numbers

CAS Registry Number

  • 60763-49-7

FDA UNII

  • 8RJ419895I

System Generated Number

  • 0060763497

Molecular Formulas

Molecular Formula

  • C26-H28-N2.C10-H11-Cl-O3

Molecular Formula Fragments

  • C10-H11-Cl-O3
  • C26-H28-N2
  • COMPONENT

Structure Descriptors

InChI

1S/C26H28N2.C10H11ClO3/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25;1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h1-17,26H,18-22H2;3-6H,1-2H3,(H,12,13)/b13-10+;

InChIKey

GNQQJMWZCJAUJT-RSGUCCNWSA-N

Smiles

C1CN(CCN1C\C=C\c1ccccc1)C(c1ccccc1)c1ccccc1.c1c(ccc(c1)OC(C(O)=O)(C)C)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 4280mg/kg (4280mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1421, 1977.
rat LD50 intraperitoneal 2gm/kg (2000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1421, 1977.
rat LD50 oral 6810mg/kg (6810mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1421, 1977.