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Substance Name: Trimethoprim hydrochloride
RN: 60834-30-2
UNII: 9XE000OU9B
InChIKey: YLCCEQZHUHUYPA-UHFFFAOYSA-N

Note

  • A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.

Molecular Formula

  • C14-H18-N4-O3.Cl-H

Molecular Weight

  • 326.782
 

Names and Synonyms

Name of Substance

  • Trimethoprim hydrochloride

Synonyms

  • EINECS 262-450-6
  • Primsol
  • Proloprim
  • Trimethoprim HCl
  • Trimplex
  • Trimplex 200
  • UNII-9XE000OU9B

Systematic Name

  • 5-((3,4,5-Trimethoxyphenyl)methyl)pyrimidine-2,4-diamine hydrochloride

Registry Numbers

CAS Registry Number

  • 60834-30-2

FDA UNII

  • 9XE000OU9B

System Generated Number

  • 0060834302

Molecular Formulas

Molecular Formula

  • C14-H18-N4-O3.Cl-H

Molecular Formula Fragments

  • C14-H18-N4-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C14H18N4O3.ClH/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;/h5-7H,4H2,1-3H3,(H4,15,16,17,18);1H

InChIKey

YLCCEQZHUHUYPA-UHFFFAOYSA-N

Smiles

Cl.COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC